Phase IB Study of Indibulin Using Positron-Emission Tomography (PET) Scans

Phase 1 Completed 20 enrolled Alaunos Therapeutics

Non-randomizedSingle-groupOpen-labelTreatment

Summary

Single arm, open label, Phase IB study of indibulin capsules in subjects with advanced solid tumors; eligible subjects will have a baseline PET scan showing a standardized uptake value (SUV) of ≥5.0 in ≥1 lesion on an 18F-FDG (fluorine-18-labeled deoxyglucose) scale.

Timeline

Start: 2007-10
Primary completion: 2008-06
Completion: 2009-03

Publications

Kapoor S, Srivastava S, Panda D. Indibulin dampens microtubule dynamics and produces synergistic antiproliferative effect with vinblastine in MCF-7 cells: Implications in cancer chemotherapy. Sci Rep. 2018 Aug 17;8(1):12363. doi: 10.1038/s41598-018-30376-y.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	indibulin	Small molecule	—	—

Indications

No indication recorded.