drugset / Trial / NCT00603720
Role of Nitric Oxide in the Impact of Aging on Myocardial Remodeling
Completed
54 enrolled
Washington University School of Medicine
National Institute on Aging (NIA) · collab
Non-randomizedParallel-groupOpen-labelBasic science
Summary
The purpose of this study is to determine, with Positron Emission Tomography (PET), the role of nitric oxide in the age-associated effect on fatty acid and glucose delivery on myocardial substrate metabolism.
Timeline
- Start
- 2005-09
- Primary completion
- 2008-06
- Completion
- 2008-06
Publications
- Background Ogawa T, Spina RJ, Martin WH 3rd, Kohrt WM, Schechtman KB, Holloszy JO, Ehsani AA. Effects of aging, sex, and physical training on cardiovascular responses to exercise. Circulation. 1992 Aug;86(2):494-503. doi: 10.1161/01.cir.86.2.494.
- Background Olivetti G, Melissari M, Capasso JM, Anversa P. Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy. Circ Res. 1991 Jun;68(6):1560-8. doi: 10.1161/01.res.68.6.1560.
- Background Coughlin SS, Neaton JD, Sengupta A, Kuller LH. Predictors of mortality from idiopathic dilated cardiomyopathy in 356,222 men screened for the Multiple Risk Factor Intervention Trial. Am J Epidemiol. 1994 Jan 15;139(2):166-72. doi: 10.1093/oxfordjournals.aje.a116978.
- Background Haldeman GA, Croft JB, Giles WH, Rashidee A. Hospitalization of patients with heart failure: National Hospital Discharge Survey, 1985 to 1995. Am Heart J. 1999 Feb;137(2):352-60. doi: 10.1053/hj.1999.v137.95495.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | L-NAME | Unknown | 4 mg/kg | Other |
| Comparator | L-arginine | Small molecule | 125 ug/kg | Other |
| Comparator | Phenylephrine | Small molecule | 10 ug/kg | Other |