drugset / Trial / NCT00605475

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ACZ885 in Patients With Type 2 Diabetes

NCT00605475

Phase 2 Completed 231 enrolled Novartis
RandomizedParallel-groupDouble-blindTreatment

Summary

The purpose of this study was to evaluate, in patients with Type 2 Diabetes Mellitus, whether Canakinumab can lower Glycosylated hemoglobin / hemoglobin A1c (HbA1c) and/or peak glucose levels in response to an oral glucose tolerance test (OGTT).

Timeline

Start
2007-12
Primary completion
2010-09
Completion
2010-09

Drugs

EvaluationDrugModalityDoseRoute
Subject Canakinumab Monoclonal antibody 0.03 mg/kg Intravenous
Subject Canakinumab Monoclonal antibody 0.1 mg/kg Intravenous
Subject Canakinumab Monoclonal antibody 0.3 mg/kg Intravenous
Subject Canakinumab Monoclonal antibody 1.5 mg/kg Intravenous
Subject Canakinumab Monoclonal antibody 10 mg/kg Intravenous
Background Metformin Small molecule