drugset / Trial / NCT00608101
Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus
Withdrawn
Vanderbilt University
RandomizedFactorialSingle-blind
Summary
The purpose of this study is to determine what corticosteroid receptor (and the dose of) is responsible for cortisol inducing hypoglycemia associated autonomic dysfunction in Type 1 DM. Specifically, we aim to determine whether stimulating the type 1 corticosteroid receptor (via fludrocortisone), the type 2 corticosteroid receptor (via dexamethasone), or both causes hypoglycemia associated autonomic dysfunction in Type 1 DM.
Timeline
- Start
- 2010-09
- Primary completion
- 2010-09
- Completion
- 2010-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dexamethasone | Small molecule | 0.18 mg | Oral |
| Subject | Dexamethasone | Small molecule | 0.375 mg | Oral |
| Subject | Dexamethasone | Small molecule | 0.75 mg | Oral |
| Subject | Fludrocortisone | Other / unclassified | 0.05 mg | Oral |
| Subject | Fludrocortisone | Other / unclassified | 0.1 mg | Oral |
| Subject | Fludrocortisone | Other / unclassified | 0.2 mg | Oral |