A Clinical Study To Test A Nasal Spray (Fluticasone Furoate Nasal Spray) For The Treatment Of Perennial (Year-round) Allergic Rhinitis

Summary

The purpose of this study is to compare the effects (effectiveness and safety) of an intranasal corticosteroid (fluticasone furoate nasal spray \[FFNS\]), with a placebo nasal spray for the treatment of perennial (year-round) allergic rhinitis.

Timeline

Start

2008-01

Primary completion

2008-06

Completion

2008-06

Outcome

Met primary endpoint

registry LEAST_SQUARES_MEAN Placebo: -2.45 (Standard Error 0.24) Points on a scale LEAST_SQUARES_MEAN Fluticasone Furoate 110 mcg: -3.19 (Standard Error 0.23) Points on a scale NCT00609674 ↗

registry analysis (superiority or other test); Placebo vs Fluticasone Furoate 110 mcg; p = 0.004; ANCOVA NCT00609674 ↗

Publications

• Background Given JT, Cheema AS, Dreykluft T, Stillerman A, Silvey M, Wu W, Snowise NG, Philpot E. Fluticasone furoate nasal spray is effective and well tolerated for perennial allergic rhinitis in adolescents and adults. Am J Rhinol Allergy. 2010 Nov-Dec;24(6):444-50. doi: 10.2500/ajra.2010.24.3534.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Fluticasone Furoate	Other / unclassified	110 ug	Intranasal

Indications