A Novel Catheter Lock Solution for Treatment of Tunneled Hemodialysis Catheter-Associated Bacteremia

Phase 1 Completed 18 enrolled University of California, San Diego

NaSingle-groupOpen-labelTreatment

Summary

The primary objective is to investigate the ability of systemic intravenous antibiotic plus antibiotic/anti-biofilm (i.e. N-acetylcysteine) lock catheter technique in eradicating uncomplicated catheter associated bacteremia and salvaging the infected vascular catheter. Secondary objectives include duration to clearance of bacteremia, future recurrence of bacteremia, need for catheter removal and death.

Timeline

Start: 2006-10
Primary completion: 2008-12
Completion: 2009-12

Publications

Aslam S, Trautner BW, Ramanathan V, Darouiche RO. Pilot trial of N-acetylcysteine and tigecycline as a catheter-lock solution for treatment of hemodialysis catheter-associated bacteremia. Infect Control Hosp Epidemiol. 2008 Sep;29(9):894-7. doi: 10.1086/590192.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	N-acetylcystein	Unknown	80 mg/ml	Other
Subject	Tigecycline	Small molecule	1 mg/ml	Other
Background	Heparin	Other / unclassified	2000 unknown	Other

A Novel Catheter Lock Solution for Treatment of Tunneled Hemodialysis Catheter-Associated Bacteremia

Summary

Timeline

Publications

Drugs

Indications