drugset / Trial / NCT00619307

Transition to Rebif New Formulation

NCT00619307

Phase 3 Completed 117 enrolled Merck KGaA, Darmstadt, Germany
RandomizedParallel-groupOpen-labelSupportive care

Summary

To assess patient satisfaction with respect to the incidence of flu-like symptoms (FLS) in patients with multiple sclerosis transitioned from current Rebif (subcutaneously injected interferon beta-1a, 44 mcg three-times-weekly) to the new formulation of Rebif (RNF) while receiving ibuprofen either prophylactically or only when necessary (PRN) after the occurence of flu-like symptoms.

Timeline

Start
2007-07
Primary completion
2008-04
Completion
2008-04

Drugs

EvaluationDrugModalityDoseRoute
Comparator Ibuprofen Small molecule 400 mg
Comparator Interferon beta-1a Protein / enzyme biologic 44 ug Subcutaneous

Indications