Pharmacokinetics of Low Dose Ritonavir

Phase 1/2 Completed 20 enrolled The HIV Netherlands Australia Thailand Research Collaboration

Non-randomizedSingle-groupOpen-labelTreatment

Summary

Compare the Pharmacokinetics of ritonavir and saquinavir(using either Saquinavir /Ritonavir 1500/100 mg or 1500/50 mg) Evaluate short term tolerability, safety and toxicity Evaluate if there is any relation between RTV concentration levels and boosting effect

Timeline

Start: 2008-01
Primary completion: 2008-04
Completion: 2008-08

Publications

Results Avihingsanon A, van der Lugt J, Kerr SJ, Gorowara M, Chanmano S, Ohata P, Lange J, Cooper DA, Phanuphak P, Burger DM, Ruxrungtham K. A low dose of ritonavir-boosted atazanavir provides adequate pharmacokinetic parameters in HIV-1-infected Thai adults. Clin Pharmacol Ther. 2009 Apr;85(4):402-8. doi: 10.1038/clpt.2008.244. Epub 2008 Dec 31.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Ritonavir	Other / unclassified	50 mg	Oral
Comparator	Ritonavir	Other / unclassified	100 mg	Oral
Comparator	Saquinavir	Small molecule	1500 mg	Oral

Pharmacokinetics of Low Dose Ritonavir

Summary

Timeline

Publications

Drugs

Indications