drugset / Trial / NCT00625092
Hyperthermic Intraperitoneal Oxaliplatin for Peritoneal Malignancies
NaSingle-groupOpen-labelTreatment
Summary
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, leucovorin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Hyperthermia therapy kills tumor cells by heating them to several degrees above normal body temperature. Peritoneal infusion of heated and nonheated chemotherapy drugs after surgery may kill more tumor cells. PURPOSE: This phase I trial is studying the side effects and best dose of hyperthermic intraperitoneal oxaliplatin followed by intraperitoneal leucovorin and fluorouracil in treating patients with peritoneal cancer.
Timeline
- Start
- 2007-10
- Primary completion
- 2010-01
- Completion
- 2011-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Oxaliplatin | Small molecule | 300 mg/m2 | Other |
| Subject | Oxaliplatin | Small molecule | 600 mg/m2 | Other |
| Background | Leucovorin | Small molecule | 200 mg/m2 | Other |
| Background | fluorouracil | Small molecule | 600 mg/m2 | Other |