Ketamine Improves Post-Thoracotomy Analgesia

Completed 44 enrolled Tel-Aviv Sourasky Medical Center

RandomizedParallel-groupQuadruple-blindTreatment

Summary

Thoracotomy for lung tumor or for minimally invasive direct coronary artery bypass (MIDCAB) surgery, may be associated with debilitating pain. Ketamine was shown to enhance opioid antinociception and prevent opioid resistance. We hypothesize that ketamine given with morphine would lower morphine consumption and narcotic related side effects after thoracotomy and provide superior analgesia to morphine given alone.

Timeline

Start: 2001-09
Primary completion: 2002-03
Completion: 2002-03

Publications

Nesher N, Ekstein MP, Paz Y, Marouani N, Chazan S, Weinbroum AA. Morphine with adjuvant ketamine vs higher dose of morphine alone for immediate postthoracotomy analgesia. Chest. 2009 Jul;136(1):245-252. doi: 10.1378/chest.08-0246. Epub 2008 Aug 27.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketamine	Small molecule	5 mg	Intravenous
Comparator	Morphine	Other / unclassified	1 mg	Intravenous
Comparator	Morphine	Other / unclassified	1.5 mg	Intravenous

Indications

No indication recorded.