drugset / Trial / NCT00631514
Interaction Between Antihypertensives and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Phase 4
Completed
88 enrolled
University of Split
Dr Ivancica Pavlicevic Family Practice Office · collab
RandomizedFactorialSingle-blindTreatment
Summary
NSAIDs may increase blood pressure and blunt the effects of many antihypertensives. Members of these drug classes differ in their propensity to such an interaction.
Timeline
- Start
- 2005-01
- Primary completion
- 2006-09
- Completion
- 2006-09
Publications
- Background Pavlicevic I, Rumboldt M, Rumboldt Z. [Untoward interactions between antihypertensives and nonsteroidal anti-inflammatory drugs]. Lijec Vjesn. 2005 Jul-Aug;127(7-8):168-72. Croatian.
- Pavlicevic I, Kuzmanic M, Rumboldt M, Rumboldt Z. Interaction between antihypertensives and NSAIDs in primary care: a controlled trial. Can J Clin Pharmacol. 2008 Fall;15(3):e372-82. Epub 2008 Oct 24.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Acetaminophen | Small molecule | 1000 mg | Oral |
| Subject | Ibuprofen | Small molecule | 400 mg | Oral |
| Subject | Ibuprofen | Small molecule | 600 mg | Oral |
| Subject | Piroxicam | Unknown | 10 mg | Oral |
| Subject | Piroxicam | Unknown | 20 mg | Oral |