Does Low-Dose Aspirin Improve Outcome in In Vitro Fertilisation/Intra Cytoplasmatic Sperm Injection (IVF/ICSI)?

NCT00644085 ↗

Phase 3 Completed 201 enrolled University Hospital, Ghent

RandomizedParallel-groupDouble-blindTreatment

Summary

To investigate the effect of daily administration of low-dose aspirin, compared to placebo, on IVF and ICSI outcome.

Timeline

Start: 2000-04
Primary completion: —
Completion: 2007-12

Outcome

Missed primary endpoint

paper could not show a significant difference in clinical pregnancy rate between the aspirin and the placebo group in a first or second IVF/ICSI cycle. PMID 19131401 ↗

Publications

Dirckx K, Cabri P, Merien A, Galajdova L, Gerris J, Dhont M, De Sutter P. Does low-dose aspirin improve pregnancy rate in IVF/ICSI? A randomized double-blind placebo controlled trial. Hum Reprod. 2009 Apr;24(4):856-60. doi: 10.1093/humrep/den476. Epub 2009 Jan 8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Aspirin	Small molecule	100 mg	Oral