drugset / Trial / NCT00655980
Vitamins in Nitrous Oxide Study
Completed
687 enrolled
Washington University School of Medicine
Foundation for Anesthesia Education and Research · collabNational Institute of General Medical Sciences (NIGMS) · collab
RandomizedFactorialQuadruple-blindDiagnostic
Summary
In this study, we want to find out if laughing gas (nitrous oxide) leads to a higher rate of cardiac complications after surgery in patients with a specific genetic profile (mutations in the MTHFR gene) and if this risk can be prevented by giving patients vitamin B12 and folate during surgery.
Timeline
- Start
- 2008-02
- Primary completion
- 2016-12
- Completion
- 2016-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Nitrous Oxide | Other / unclassified | — | — |
| Subject | Vitamin B12 | Other / unclassified | 1 mg | Intravenous |
| Subject | folic acid | Other / unclassified | 5 mg | Intravenous |