Study Comparing a Soybean Oil-Based With an Olive Oil-Based Lipid Emulsion in ICU Patients Requiring TPN

Phase 2/3 Completed 100 enrolled Emory University Baxter Healthcare Corporation · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

Many hospitalized patients who are malnourished or not eating receive intravenous feeding or total parenteral nutrition (TPN). Despite improving nutrition, TPN may increase the risk of infections and hospital complications. We do not know why TPN increases hospital complications, but it may be caused by the high sugar or fat content in TPN solutions.

Timeline

Start: 2008-11
Primary completion: 2010-12
Completion: 2010-12

Publications

Results Umpierrez GE, Spiegelman R, Zhao V, Smiley DD, Pinzon I, Griffith DP, Peng L, Morris T, Luo M, Garcia H, Thomas C, Newton CA, Ziegler TR. A double-blind, randomized clinical trial comparing soybean oil-based versus olive oil-based lipid emulsions in adult medical-surgical intensive care unit patients requiring parenteral nutrition. Crit Care Med. 2012 Jun;40(6):1792-8. doi: 10.1097/CCM.0b013e3182474bf9.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	ClinOleic	Other / unclassified	20 %	Intravenous
Comparator	Intralipid	Other / unclassified	20 %	Intravenous

Indications

No indication recorded.