drugset / Trial / NCT00678730
Pharmacogenetics of Cannabinoid Response
RandomizedCrossoverQuadruple-blindBasic science
Summary
This study attempts to examine genetic influences on the effects of tetrahydrocannabinol (Δ9-THC), the active ingredient of marijuana, cannabis, "ganja", or "pot".
Timeline
- Start
- 2007-08-23
- Primary completion
- 2014-09-11
- Completion
- 2014-09-11
Publications
- Ranganathan M, De Aquino JP, Cortes-Briones JA, Radhakrishnan R, Pittman B, Bhakta S, D'Souza DC. Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humans. Psychopharmacology (Berl). 2019 Nov;236(11):3209-3219. doi: 10.1007/s00213-019-05273-5. Epub 2019 Jun 11.
- Ranganathan M, Radhakrishnan R, Addy PH, Schnakenberg-Martin AM, Williams AH, Carbuto M, Elander J, Pittman B, Andrew Sewell R, Skosnik PD, D'Souza DC. Tetrahydrocannabinol (THC) impairs encoding but not retrieval of verbal information. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):176-183. doi: 10.1016/j.pnpbp.2017.06.019. Epub 2017 Jun 20.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | delta-9-tetrahydrocannabinol | Other / unclassified | 0.005 mg/kg | Intravenous |
| Comparator | delta-9-tetrahydrocannabinol | Other / unclassified | 0.025 mg/kg | Intravenous |
| Comparator | delta-9-tetrahydrocannabinol | Other / unclassified | 0.05 mg/kg | Intravenous |
Indications
No indication recorded.