Combination Metformin and Oral Contraception for Polycystic Ovary Syndrome (PCOS)

Summary

The purpose of this research study is to determine if adding Metformin, a drug that reduces insulin resistance, to birth control pills will reduce the risk of developing type 2 diabetes, high blood pressure. high lipid levels and heart disease in women with PCOS

Timeline

Start

2005-11

Primary completion

2009-12

Completion

2010-01

Outcome

Outcome not reported

Stopped (Enrollment): “Lack of recruitment”

Publications

• Results Essah PA, Arrowood JA, Cheang KI, Adawadkar SS, Stovall DW, Nestler JE. Effect of combined metformin and oral contraceptive therapy on metabolic factors and endothelial function in overweight and obese women with polycystic ovary syndrome. Fertil Steril. 2011 Aug;96(2):501-504.e2. doi: 10.1016/j.fertnstert.2011.05.091. Epub 2011 Jul 5.

Drugs

Indications