Drug Interaction Study Between AZD3355 and Nexium

Phase 1 Completed 30 enrolled AstraZeneca

RandomizedCrossoverOpen-labelBasic science

Summary

The purpose of the study is to evaluate if AZD3355 and Nexium interact with each other or not, i.e. show the same or altered plasma concentration profiles when co-administered compared to administered alone.

Timeline

Start: 2008-03
Primary completion: 2008-06
Completion: 2008-06

Outcome

Met primary endpoint

paper were within the recognized boundaries of bioequivalence (0.8-1.25). PMID 21171670 ↗

Publications

Niazi M, Silberg DG, Miller F, Ruth M, Holmberg AA. Evaluation of the pharmacokinetic interaction between lesogaberan (AZD3355) and esomeprazole in healthy subjects. Drugs R D. 2010;10(4):243-51. doi: 10.2165/11588180-000000000-00000.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Esomeprazole	Small molecule	40 mg	Oral
Subject	lesogaberan	Small molecule	150 mg	Oral