Phenethyl Isothiocyanate in Preventing Lung Cancer in Smokers

Summary

RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. The use of phenethyl isothiocyanate may prevent lung cancer in people who smoke cigarettes. PURPOSE: This randomized clinical trial is studying phenethyl isothiocyanate to see how well it works in preventing lung cancer in smokers.

Timeline

Start

2009-02

Primary completion

2013-01

Completion

2013-01

Outcome

Met primary endpoint

registry analysis (superiority or other test); Placebo vs PEITC; p = 0.023; Mean Difference (Final Values) -7.7 (95% CI -13.8 to -1.2); Mixed Models Analysis NCT00691132 ↗

paper Overall, the NNK metabolic activation ratio was reduced by 7.7% with PEITC treatment (P = 0.023). PMID 26951845 ↗

Publications

• Results Yuan JM, Stepanov I, Murphy SE, Wang R, Allen S, Jensen J, Strayer L, Adams-Haduch J, Upadhyaya P, Le C, Kurzer MS, Nelson HH, Yu MC, Hatsukami D, Hecht SS. Clinical Trial of 2-Phenethyl Isothiocyanate as an Inhibitor of Metabolic Activation of a Tobacco-Specific Lung Carcinogen in Cigarette Smokers. Cancer Prev Res (Phila). 2016 May;9(5):396-405. doi: 10.1158/1940-6207.CAPR-15-0380. Epub 2016 Mar 7.
• Dinh TN, Parat MO, Ong YS, Khaw KY. Anticancer activities of dietary benzyl isothiocyanate: A comprehensive review. Pharmacol Res. 2021 Jul;169:105666. doi: 10.1016/j.phrs.2021.105666. Epub 2021 May 12.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	phenethyl isothiocyanate	Small molecule	10 mg	Oral

Indications