A Study to Asses the Effect of MK0663 in the Treatment of Patients With Postoperative Dental Pain (0663-092)

Summary

The purpose of this study is to compare the pain relieving effect of different doses of MK0663 with placebo and other pain relievers/analgesics in patients with postoperative dental pain. Pain intensity and relief will be measured by the total pain relief score (TOPAR) and patient evaluation.

Timeline

Start

2008-06

Primary completion

2008-12

Completion

2009-01

Outcome

Met primary endpoint

registry analysis (unspecified test); Placebo vs Etoricoxib 120 mg; p <0.001; ANOVA; note: 0.05 critical level was used. NCT00694369 ↗

registry analysis (unspecified test); Placebo vs Etoricoxib 90 mg; p <0.001; ANOVA; note: 0.05 critical level was used. NCT00694369 ↗

Publications

• Brown JD, Daniels SE, Bandy DP, Ko AT, Gammaitoni A, Mehta A, Boice JA, Losada MC, Peloso PM. Evaluation of multiday analgesia with etoricoxib in a double-blind, randomized controlled trial using the postoperative third-molar extraction dental pain model. Clin J Pain. 2013 Jun;29(6):492-8. doi: 10.1097/AJP.0b013e318260c144.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Acetaminophen	Small molecule	600 mg	—
Comparator	Codeine	Small molecule	60 mg	—
Subject	Etoricoxib	Small molecule	90 mg	—
Subject	Etoricoxib	Small molecule	120 mg	—
Comparator	Ibuprofen	Small molecule	600 mg	—

Indications

No indication recorded.