Clomiphene in Males With Prolactinomas and Persistent Hypogonadism

Summary

Prolactinomas are usually associated with hypogonadotropic hypogonadism in both sexes. Clomiphene citrate is a well known selective estrogen receptor modulator that increases gonadotropin secretion via hypothalamic-pituitary action. We conducted a prospective, open label clinical trial of CC to evaluate its effects in reverting persistent HH in male patients with prolactinomas under dopaminergic agonist treatment.

Timeline

Start

2004-06

Primary completion

2005-06

Completion

2005-06

Drugs

Indications