Analgesic Effect of Ibuprofen, Paracetamol (Acetaminophen), and Paracetamol (Acetaminophen) Plus Codeine on Acute Pain

Phase 4 Completed 350 enrolled Ullevaal University Hospital University of Oslo · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this placebo controlled clinical trial is to evaluate the dose response relationship of ibuprofen in doses from 400 mg to 800 mg and paracetamol (acetaminophen)in doses from 500 mg to 1000 mg compared with paracetamol (acetaminophen)1000 mg plus codeine 60 mg on acute postoperative pain after surgical removal of impacted third molars.

Timeline

Start: 2007-06
Primary completion: 2009-12
Completion: 2009-12

Publications

Lyngstad G, Skjelbred P, Swanson DM, Skoglund LA. Analgesic effect of oral ibuprofen 400, 600, and 800 mg; paracetamol 500 and 1000 mg; and paracetamol 1000 mg plus 60 mg codeine in acute postoperative pain: a single-dose, randomized, placebo-controlled, and double-blind study. Eur J Clin Pharmacol. 2021 Dec;77(12):1843-1852. doi: 10.1007/s00228-021-03231-9. Epub 2021 Oct 16.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Acetaminophen	Small molecule	500 mg	—
Comparator	Acetaminophen	Small molecule	1000 mg	—
Comparator	Codeine	Small molecule	60 mg	—
Comparator	Ibuprofen	Small molecule	400 mg	—
Comparator	Ibuprofen	Small molecule	600 mg	—
Comparator	Ibuprofen	Small molecule	800 mg	—

Indications

No indication recorded.