drugset / Trial / NCT00707889

Phase 2 Study of ABT-869 in Combination With mFOLFOX6 Versus Bevacizumab in Combination With mFOLFOX6 to Treat Advanced Colorectal Cancer

NCT00707889

Phase 2 Completed 159 enrolled AbbVie Genentech, Inc. · collab
RandomizedParallel-groupOpen-labelTreatment

Summary

To determine the effect of ABT-869 plus mFOLFOX6 compared to bevacizumab plus mFOLFOX6 on disease progression in advanced colorectal cancer.

Timeline

Start
2008-10
Primary completion
2012-05
Completion
2012-05

Drugs

EvaluationDrugModalityDoseRoute
Comparator ABT-869 Unknown 7.5 mg Oral
Comparator ABT-869 Unknown 12.5 mg Oral
Comparator Bevacizumab Monoclonal antibody 10 mg/kg Intravenous
Comparator Leucovorin Small molecule 400 mg/m2 Intravenous
Comparator Oxaliplatin Small molecule 85 mg/m2 Intravenous
Comparator fluorouracil Small molecule 400 mg/m2 Intravenous
Comparator fluorouracil Small molecule 2400 mg/m2 Intravenous