Rapid Effects of Hydrocortisone on Glucose-induced Insulin Secretion in Healthy Humans

Phase 4 Completed 10 enrolled Medical University of Vienna

RandomizedCrossoverSingle-blindBasic science

Summary

The purpose of this study is to investigate the effect of hydrocortisone on glucose-induced insulin secretion and sensitivity, by means of an intravenous glucose tolerance test with frequent sampling (FSIGT) followed by minimal model analysis. In a randomized single-blind cross-over design, the subjects will receive either hydrocortisone or placebo 4 minutes before an intravenous glucose load.

Timeline

Start: 2008-06
Primary completion: 2008-10
Completion: 2008-12

Publications

Results Vila G, Krebs M, Riedl M, Baumgartner-Parzer SM, Clodi M, Maier C, Pacini G, Luger A. Acute effects of hydrocortisone on the metabolic response to a glucose load: increase in the first-phase insulin secretion. Eur J Endocrinol. 2010 Aug;163(2):225-31. doi: 10.1530/EJE-10-0282. Epub 2010 May 18.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Hydrocortisone	Other / unclassified	0.6 mg/kg	Intravenous
Background	Glucose	Unknown	330 mg/kg	Intravenous

Indications

No indication recorded.