Drugs / Hydrocortisone
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Hydrocortisone

Other / unclassified

Developed for
infectious disease with sepsis · congenital adrenal hyperplasia · adrenocortical insufficiency · post-traumatic stress disorder · acute lymphoblastic leukemia · leukemia · prostate cancer · atopic eczema
+105 more · bronchopulmonary dysplasia · cardiac arrest · psoriasis · atrial fibrillation · classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency · dry eye syndrome · herpes labialis · obesity disorder · primary adrenal insufficiency · acute respiratory distress syndrome · adrenal gland hyperfunction · COVID-19 · depressive disorder · exanthem · major depressive disorder · myelodysplastic syndrome · pancreatitis · pneumonia · polycystic ovary syndrome · secondary adrenal insufficiency · acute otitis externa · acute pancreatitis · alopecia areata · asthma · borderline personality disorder · cardiogenic shock · circadian rhythm sleep disorder, jet lag type · cirrhosis of liver · classic congenital adrenal hyperplasia · colitis · congenital heart disease · conjunctivitis · Crohn disease · dengue disease · diabetes mellitus · disease of the tendon · encephalomalacia · eye adnexa disorder · glaucoma · heart failure · hemophagocytic syndrome · hemorrhoid · HIV infectious disease · hypopituitarism · influenza · interstitial cystitis · intussusception · lymphoblastic lymphoma · multiple symmetric lipomatosis · necrotizing enterocolitis · necrotizing soft tissue infection · opiate dependence · perinatal asphyxia · phimosis · phobic disorder · post-cardiac arrest syndrome · primary aldosteronism · proctitis · pyogenic granuloma · rheumatic disorder · snakebite envenomation · stomatitis · sudden sensorineural hearing loss · T-cell childhood acute lymphocytic leukemia · temporomandibular joint disorder · toxic dermatosis · type 1 diabetes mellitus · ulcerative colitis · viral hemorrhagic fever · viral pneumonia · vulvovaginal candidiasis · acute adrenal insufficiency · acute hypotension · acute lung injury · acute stress disorder · adrenal gland disorder · alcohol dependence · autoinflammatory syndrome · B-cell acute lymphoblastic leukemia · benign shuddering attacks · brain hypoxia - ischemia · chronic obstructive pulmonary disease · fibromyalgia · headache disorder · hypotensive disorder · internal hemorrhoid · intertrigo · intracranial hypotension · multiple organ dysfunction syndrome · nervous system injury · nosocomial infection · oral submucous fibrosis · orthostatic hypotension · osteoarthritis, knee · otitis media · pancreas disorder · pituitary deficiency · prurigo nodularis · rheumatoid arthritis · Sjogren syndrome · skin disorder · ST-elevation myocardial infarction · vascular disorder · vascular insufficiency disorder · vitiligo
Investigated by
Neurocrine UK Limited · National Cancer Institute (NCI) · Assistance Publique - Hôpitaux de Paris · Simbec Research · Wayne State University · National Institute on Drug Abuse (NIDA)
+278 more · University of Athens · Beth Israel Deaconess Medical Center · Brush Clinical Research Ltd. · Children's Oncology Group · Eleonora Seelig · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · LEO Pharma · Medical Matters International Ltd · National Institute of Allergy and Infectious Diseases (NIAID) · National Institute of Mental Health (NIMH) · National Institutes of Health Clinical Center (CC) · Northern Jiangsu People's Hospital · Stanford University · University of Virginia · Voet Consulting · Amgen · Baylor College of Medicine · Boston Children's Hospital · Cairo University · Central Institute of Mental Health, Mannheim · Charite University, Berlin, Germany · Cristcot LLC · Erasmus Medical Center · Haukeland University Hospital · Helsinki University Central Hospital · Hoffmann-La Roche · Imperial College London · Insel Gruppe AG, University Hospital Bern · Jinling Hospital, China · Kuopio University Hospital · Medical University of Vienna · Medivir · Nanjing PLA General Hospital · Nantes University Hospital · National Alliance for Research on Schizophrenia and Depression · National Center for Research Resources (NCRR) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · National Institutes of Health (NIH) · PETHEMA Foundation · Rigshospitalet, Denmark · Tampere University Hospital · Tanta University · UMC Utrecht · University Hospital, Tours · University of California, San Diego · University of California, San Francisco · University of Texas Southwestern Medical Center · University of Thessaly · University of Zurich · Yale University · Aarhus University Hospital · Academic Medical Center - University of Amsterdam · Agnes · Ain Shams University · Albert Einstein Healthcare Network · Alberta Children's Hospital · American Heart Association · American Society of Clinical Oncology · Ascension Health · Assiut University · Association Niçoise de Réanimation Médicale · Auburn University · Australian and New Zealand Intensive Care Research Centre · Azienda Ospedaliera Universitaria Integrata Verona · Azienda Ospedaliera di Padova · BC Research Inc. · Baqiyatallah Medical Sciences University · Bayer · Beckman Coulter, Inc. · Beijing Tiantan Hospital · Benha University · Beni-Suef University · Berry Consultants · Bionical Emas · all 284 on the full record

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved EU (EMA) Plenadren 2011-11-03 europa.eu
Approved US (FDA) HYDROCORTONE 1951-12-21 fda.gov

Trials 213 · started per year

today
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EU approved 2011
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 013 trials
Phase 0 NCT07612631 Jun 2026 → Jun 2031 expected alcohol-related disorders Rajesh Narendran Recruiting No outcome recorded
Phase 0 NCT06430580 Sep 2024 → Sep 2026 expected cannabis dependence Florida State University Recruiting No outcome recorded
Phase 0 NCT05919992 May 2023 → Jul 2024 glucocorticoid therapy, response to Eleonora Seelig Completed No outcome recorded
Phase 0 NCT05167084 Feb 2022 → Jun 2023 glucocorticoid therapy, response to Eleonora Seelig Completed No outcome recorded
Phase 0 NCT04896489 May 2021 → Mar 2022 alcohol-related disorders Yale University Completed No outcome recorded
Phase 0 NCT04148261 Dec 2020 → Dec 2022 depressive disorder Stanford University Withdrawn No outcome recorded
Phase 0 NCT04037605 Feb 2020 → Jul 2022 overdue Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center Active not recruiting No outcome recorded
Phase 0 NCT04435912 Jul 2019 → Apr 2020 University of Jordan Completed No outcome recorded
Phase 0 NCT01422733 Jun → Jul 2018 obesity disorder, polycystic ovary syndrome University of Virginia Withdrawn No outcome recorded
Phase 0 NCT01422707 Jan → Jul 2018 obesity disorder, polycystic ovary syndrome University of Virginia Withdrawn No outcome recorded
Phase 114 trials
Phase 1 NCT04852458 May 2021 → Nov 2022 University of Michigan Completed No outcome recorded
Phase 1 NCT03718234 Jan 2019 → Feb 2023 adrenal gland hyperfunction, congenital adrenal hyperplasia, disorder of sexual differentiation, hyperplasia +1 University of Minnesota Completed No outcome recorded
Phase 1 NCT03311932 Apr → Jul 2018 adrenocortical insufficiency Neurocrine UK Limited Completed No outcome recorded
Phase 1 NCT03343327 Feb → Apr 2018 adrenocortical insufficiency Neurocrine UK Limited Completed No outcome recorded
Phase 1 NCT03178214 May → Jul 2017 adrenocortical insufficiency Neurocrine UK Limited Completed No outcome recorded
Phase 1 NCT03142893 May 2017 → Oct 2020 overdue Peter y. Liu Active not recruiting No outcome recorded
Phase 1 NCT02722200 May 2016 → Jul 2017 obesity disorder Yale University Completed No outcome recorded
Phase 1 NCT02671058 Mar → May 2016 Cristcot LLC Completed No outcome recorded
Phase 1 NCT03670212 Jan → Oct 2016 Wayne State University Completed No outcome recorded
Phase 1 NCT01960530 Oct 2013 → Nov 2014 adrenocortical insufficiency Neurocrine UK Limited Completed No outcome recorded
Phase 1/29 trials
Phase 1/2 NCT05157360 Sep 2021 → May 2023 infectious disease with sepsis, necrotizing soft tissue infection Ascension Health Terminated No outcome recorded
Phase 1/2 NCT03649633 Sep 2018 → Jan 2023 infectious disease with sepsis University of Athens Terminated No outcome recorded
Phase 1/2 NCT03015246 Dec 2016 → Jun 2020 heroin dependence Wayne State University Completed No outcome recorded
Phase 1/2 NCT02790788 Nov 2016 → May 2018 cardiac arrest University of Athens Completed No outcome recorded
Phase 1/2 NCT02096510 Mar 2014 → Dec 2016 congenital adrenal hyperplasia Haukeland University Hospital Completed No outcome recorded
Phase 1/2 NCT02922374 Jan 2013 → Jun 2016 colitis Jinling Hospital, China Unknown No outcome recorded
Phase 1/2 NCT00673270 May → Oct 2008 hypertensive disorder Rennes University Hospital Terminated No outcome recorded
Phase 1/2 NCT00676585 Oct 2007 → Apr 2014 cardiac arrest Beth Israel Deaconess Medical Center Completed No outcome recorded
Phase 1/2 NCT00519818 Aug 2007 → May 2009 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency Neurocrine UK Limited Completed No outcome recorded
Phase 239 trials
Phase 2 NCT04231708 Oct 2026 → Dec 2028 expected substance-related disorder Wayne State University Not yet recruiting No outcome recorded
Phase 2 NCT06381661 May 2026 → Jun 2028 expected infectious disease with sepsis Assistance Publique - Hôpitaux de Paris Not yet recruiting No outcome recorded
Phase 2 NCT06895473 Jun 2025 → Apr 2027 expected hematopoietic and lymphoid system neoplasm OHSU Knight Cancer Institute Recruiting No outcome recorded
Phase 2 NCT04180969 Apr 2023 Wayne State University Withdrawn No outcome recorded
Phase 2 NCT05160506 Mar 2022 → Jan 2027 expected acute pancreatitis Beth Israel Deaconess Medical Center Recruiting No outcome recorded
Phase 2 NCT05112354 Dec 2019 → Jun 2021 sudden sensorineural hearing loss Assiut University Completed No outcome recorded
Phase 2 NCT03710187 Nov 2018 → Sep 2019 infectious disease with sepsis University of Tennessee Medical Center Completed No outcome recorded
Phase 2 NCT03592693 Sep 2018 → Jan 2023 University of Athens Terminated No outcome recorded
Phase 2 NCT03422159 Feb 2018 → Jun 2019 infectious disease with sepsis Community Medical Center, Toms River, NJ Completed No outcome recorded
Phase 2 NCT02465606 Jul 2015 → May 2016 atopic eczema Hoffmann-La Roche Completed No outcome recorded
Phase 2/39 trials
Phase 2/3 NCT06496997 Aug 2024 → Aug 2025 overdue acute respiratory distress syndrome Fayoum University Recruiting No outcome recorded
Phase 2/3 NCT05534334 May → Nov 2022 pyogenic granuloma Beni-Suef University Unknown No outcome recorded
Phase 2/3 NCT03682393 Jan 2020 → Dec 2022 atrial fibrillation Kuopio University Hospital Withdrawn No outcome recorded
Phase 2/3 NCT03380507 Mar 2018 → Oct 2019 infectious disease with sepsis Hamad Medical Corporation Terminated No outcome recorded
Phase 2/3 NCT03389555 Feb 2018 → Nov 2019 infectious disease with sepsis, metabolic disease Beth Israel Deaconess Medical Center Completed No outcome recorded
Phase 2/3 NCT02552251 Aug 2012 → Dec 2015 classic congenital adrenal hyperplasia University Hospital, Caen Unknown No outcome recorded
Phase 2/3 NCT01063569 Feb 2010 → Dec 2012 primary adrenal insufficiency Haukeland University Hospital Completed No outcome recorded
Phase 2/3 NCT01047670 May 2008 → ? Unidade de Terapia Intensiva Unknown No outcome recorded
Phase 2/3 NCT00563303 Nov 2006 Nantes University Hospital Completed No outcome recorded
Phase 352 trials
Phase 3 NCT07332325 Oct 2026 → Mar 2029 expected infectious disease with sepsis, tuberculosis University of Virginia Not yet recruiting No outcome recorded
Phase 3 NCT07037043 Apr 2025 → May 2028 expected Centre Hospitalier Universitaire, Amiens Recruiting No outcome recorded
Phase 3 NCT05816226 Jun 2023 → Jan 2026 overdue temporomandibular joint disorder University of the Pacific Recruiting No outcome recorded
Phase 3 NCT05668455 May 2023 → Dec 2025 overdue Agnes Recruiting No outcome recorded
Phase 3 NCT05299554 Apr 2022 → Jan 2026 congenital adrenal hyperplasia Immedica Pharma AB Completed No outcome recorded
Phase 3 NCT04404400 Feb 2022 → Feb 2026 overdue adrenocortical insufficiency Assistance Publique - Hôpitaux de Paris Recruiting No outcome recorded
Phase 3 NCT04821583 Jun 2021 → Sep 2022 multiple symmetric lipomatosis Erasmus Medical Center Unknown No outcome recorded
Phase 3 NCT04591990 May 2021 → Dec 2025 overdue post-cardiac arrest syndrome Assistance Publique - Hôpitaux de Paris Recruiting No outcome recorded
Phase 3 NCT04469686 Dec 2020 → Jul 2024 proctitis Cristcot LLC Completed No outcome recorded
Phase 3 NCT04359511 Jul 2020 COVID-19 University Hospital, Tours Withdrawn No outcome recorded
Phase 444 trials
Phase 4 NCT07558811 Apr → Dec 2026 expected primary aldosteronism Ruijin Hospital Not yet recruiting No outcome recorded
Phase 4 NCT07383103 Mar 2026 → Dec 2028 expected infectious disease with sepsis Northern Jiangsu People's Hospital Recruiting No outcome recorded
Phase 4 NCT07695337 Jan → Jul 2026 infectious disease with sepsis Benha University Completed No outcome recorded
Phase 4 NCT07124650 Sep 2025 → Dec 2026 expected Saint Petersburg State University, Russia Recruiting No outcome recorded
Phase 4 NCT07262957 Sep 2025 → Sep 2027 expected ampulla of vater adenocarcinoma, cholangiocarcinoma, cystic neoplasm, neuroendocrine neoplasm +3 Academic Medical Center - University of Amsterdam Recruiting No outcome recorded
Phase 4 NCT07248761 Feb 2025 → Jun 2026 overdue hyperglycemia, neonatal sepsis, patent ductus arteriosus, perinatal asphyxia +4 Coordinación de Investigación en Salud, Mexico Active not recruiting No outcome recorded
Phase 4 NCT06679816 Dec 2024 → Dec 2025 overdue pituitary gland adenoma Beijing Tiantan Hospital Recruiting No outcome recorded
Phase 4 NCT06435481 Sep 2024 → Sep 2025 overdue adrenocortical insufficiency Hospital Universitari Vall d'Hebron Research Institute Not yet recruiting No outcome recorded
Phase 4 NCT06018727 Jul 2024 → Jul 2025 borderline personality disorder University of North Carolina, Chapel Hill Withdrawn No outcome recorded
Phase 4 NCT06637384 Mar → Apr 2024 diabetes mellitus Rimsha Rasheed Completed No outcome recorded
Phase not applicable33 trials
NCT07313670 Jul → Dec 2025 infectious disease with sepsis Muhammad Aamir Latif Completed No outcome recorded
NCT06556277 Sep 2024 → Feb 2026 overnutrition Eleonora Seelig Completed No outcome recorded
NCT06217939 Jun 2024 → Jun 2026 overdue infectious disease with sepsis Siriraj Hospital Recruiting No outcome recorded
NCT04597762 Aug 2020 → Mar 2021 dry eye syndrome Hospital Hietzing Completed No outcome recorded
NCT04465539 Jul 2020 → Feb 2024 Tanta University Completed No outcome recorded
NCT04280497 Apr 2020 → Dec 2025 overdue infectious disease with sepsis Assistance Publique - Hôpitaux de Paris Recruiting No outcome recorded
NCT04160676 Dec 2019 → Jul 2021 infectious disease with sepsis Tanta University Completed No outcome recorded
NCT04536129 Nov 2019 → Mar 2020 eye adnexa disorder, glaucoma University of Molise Completed No outcome recorded
NCT03748537 Jan 2017 → Dec 2019 infectious disease with sepsis Chiang Mai University Completed No outcome recorded
NCT02580240 Sep 2015 → Sep 2016 infectious disease with sepsis Northern Jiangsu People's Hospital Completed No outcome recorded
Also used as a comparator or background therapy in 259 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 06 trials
Phase 0 NCT07059975 Background Oct 2025 → Oct 2028 expected childhood acute myeloid leukemia Joanna Yi Recruiting No outcome recorded
Phase 0 NCT06942039 Background Sep 2025 → Dec 2030 expected atypical teratoid rhabdoid tumor, childhood medulloblastoma, embryonal tumor with multilayered rosettes, ependymoblastoma +5 C17 Council Recruiting No outcome recorded
Phase 0 NCT05674253 Comparator Dec 2022 → Jun 2023 atrial fibrillation Ain Shams University Unknown No outcome recorded
Phase 0 NCT05008146 Background Dec 2020 → Sep 2028 expected substance-related disorder Rajesh Narendran Recruiting No outcome recorded
Phase 0 NCT02256865 Comparator Oct 2014 → Nov 2017 Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center Completed No outcome recorded
Phase 127 trials
Phase 1 NCT07498465 Background Sep 2026 → Nov 2028 childhood acute lymphoblastic leukemia, childhood acute myeloid leukemia, mixed phenotype acute leukemia Children's Oncology Group Withdrawn No outcome recorded
Phase 1 NCT06504160 Background May 2025 → Dec 2026 expected atopic eczema National Institute of Allergy and Infectious Diseases (NIAID) Recruiting No outcome recorded
Phase 1 NCT06247787 Background Feb 2025 → Mar 2028 expected childhood acute myeloid leukemia, childhood myelodysplastic syndrome, juvenile myelomonocytic leukemia Children's Oncology Group Recruiting No outcome recorded
Phase 1 NCT06177067 Background Apr 2024 → Oct 2026 expected acute leukemia of ambiguous lineage St. Jude Children's Research Hospital Recruiting No outcome recorded
Phase 1 NCT06136598 Background Jan 2024 → Mar 2026 castration-resistant prostate carcinoma Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1/223 trials
Phase 1/2 NCT07175415 Background Oct 2026 → Oct 2031 expected T lymphoblastic leukemia/lymphoma, acute lymphoblastic leukemia Princess Maxima Center for Pediatric Oncology Not yet recruiting No outcome recorded
Phase 1/2 NCT07387926 Background Jul 2026 → Sep 2033 expected B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2), acute lymphoblastic leukemia Novartis Pharmaceuticals Recruiting No outcome recorded
Phase 1/2 NCT05751044 Background Oct 2025 → Feb 2032 expected T lymphoblastic leukemia/lymphoma, acute lymphoblastic leukemia Princess Maxima Center for Pediatric Oncology Recruiting No outcome recorded
Phase 1/2 NCT05745714 Background Oct 2025 → Feb 2032 expected T-lymphoblastic lymphoma, acute lymphoblastic leukemia Princess Maxima Center for Pediatric Oncology Recruiting No outcome recorded
Phase 1/2 NCT05658640 Background Nov 2023 → Apr 2029 expected T-lymphoblastic lymphoma, acute lymphoblastic leukemia Princess Maxima Center for Pediatric Oncology Recruiting No outcome recorded
Phase 277 trials
Phase 2 NCT07686107 Background Aug 2026 → Dec 2029 expected acute myeloid leukemia Therapeutic Advances in Childhood Leukemia Consortium Not yet recruiting No outcome recorded
Phase 2 NCT06446245 Background Aug 2025 → Nov 2027 expected meningeal tuberculosis National University Hospital, Singapore Recruiting No outcome recorded
Phase 2 NCT06979596 Background Aug 2025 → Nov 2027 expected cancer Merck Sharp & Dohme LLC Recruiting No outcome recorded
Phase 2 NCT06317662 Background Jun 2025 → Dec 2028 expected B-cell acute lymphoblastic leukemia, acute leukemia of ambiguous lineage National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 2 NCT06390319 Background Dec 2024 → Dec 2027 expected T-cell acute lymphoblastic leukemia, T-cell non-Hodgkin lymphoma, mixed phenotype acute leukemia St. Jude Children's Research Hospital Recruiting No outcome recorded
Phase 2/36 trials
Phase 2/3 NCT07072585 Background Aug 2026 → Sep 2035 expected T-cell acute lymphoblastic leukemia, T-lymphoblastic lymphoma Children's Oncology Group Not yet recruiting No outcome recorded
Phase 2/3 NCT03371784 Comparator Mar 2018 → Dec 2019 ST-elevation myocardial infarction Iuliu Hatieganu University of Medicine and Pharmacy Unknown No outcome recorded
Phase 2/3 NCT02700828 Comparator Feb 2016 → Nov 2017 brain hypoxia - ischemia, perinatal asphyxia Semmelweis University Completed No outcome recorded
Phase 2/3 NCT02451774 Comparator Jan 2015 → Dec 2019 childhood acute lymphoblastic leukemia Ramón Óscar González-Ramella, Ph.D Unknown No outcome recorded
Phase 2/3 NCT00720109 Background Jul 2008 → Dec 2014 B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2), acute lymphoblastic leukemia National Cancer Institute (NCI) Completed No outcome recorded
Phase 349 trials
Phase 3 NCT07536399 Comparator Apr 2026 → Dec 2027 expected mouth disorder, temporomandibular joint disorder Weill Medical College of Cornell University Not yet recruiting No outcome recorded
Phase 3 NCT06136624 Background Dec 2023 → Aug 2028 expected metastatic prostate carcinoma Merck Sharp & Dohme LLC Recruiting No outcome recorded
Phase 3 NCT06136650 Background Dec 2023 → May 2028 expected castration-resistant prostate carcinoma Merck Sharp & Dohme LLC Recruiting No outcome recorded
Phase 3 NCT05894954 Background Jul 2023 → Oct 2025 cognitive impairment with or without cerebellar ataxia, dementia Alzheimer's Prevention and Reversal Project, Inc. Completed No outcome recorded
Phase 3 NCT05063994 Comparator May 2022 → Feb 2024 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency Neurocrine UK Limited Completed No outcome recorded
Phase 439 trials
Phase 4 NCT07703098 Comparator Sep 2026 → Sep 2029 expected adrenocortical insufficiency University Medical Centre Ljubljana Not yet recruiting No outcome recorded
Phase 4 NCT07494084 Comparator Jul 2026 → Mar 2029 expected circadian rhythm sleep disorder, shift work type Washington State University Not yet recruiting No outcome recorded
Phase 4 NCT06892197 Comparator Mar 2026 → Aug 2030 expected pneumonia Copenhagen Respiratory Research Recruiting No outcome recorded
Phase 4 NCT06892210 Comparator Mar 2026 → Aug 2030 expected chronic obstructive pulmonary disease Copenhagen Respiratory Research Recruiting No outcome recorded
Phase 4 NCT06982183 Comparator May 2025 → Sep 2026 expected acute stress disorder Walter Reed Army Institute of Research (WRAIR) Recruiting No outcome recorded
Phase not applicable30 trials
NCT07558135 Comparator Sep 2026 → Sep 2028 expected adrenal gland disorder King's College Hospital NHS Trust Not yet recruiting No outcome recorded
NCT05716607 Comparator Jan 2025 → Jul 2026 autoimmune polyendocrinopathy, diabetes mellitus, primary adrenal insufficiency Vastra Gotaland Region Withdrawn No outcome recorded
NCT06723626 Comparator Jul 2024 → Nov 2025 overdue infectious disease with sepsis Southeast University, China Recruiting No outcome recorded
NCT06930456 Comparator Mar 2024 → Mar 2025 overdue hypotensive disorder Nada kamel Elgamal Enrolling by invitation No outcome recorded
NCT06576245 Background Sep 2023 → Feb 2024 dry eye syndrome University of Seville Completed No outcome recorded
Phase not stated2 trials
NCT04456439 Background COVID-19–associated multisystem inflammatory syndrome in children Mesoblast, Ltd. No longer available No outcome recorded
NCT05974410 Background Hodgkins lymphoma, brain neoplasm, breast cancer, desmoplastic small round cell tumor +10 AVM Biotechnology Inc Available No outcome recorded

Press releases naming this drug 2 releases

DateIssuerRelease
2021-02-10 Gilead Sciences Kite Announces New ZUMA-1 Cohort Analysis Evaluating Prophylactic Corticosteroid Use With Yescarta® in Patients With Relapsed or Refractory Large B-cell lymphoma gilead.com
2020-12-22 Amgen Update On SOURCE Phase 3 Trial For Tezepelumab In Patients With Severe, Oral Corticosteroid-Dependent Asthma amgen.com

Evidence & citations 36 cited values

Every value below carries the sentence it was read from. 476 sources stand behind the page.

FieldValueCited text
Known as hydrocortisone “Patients were randomized to receive either preservative-free hydrocortisone 0.335% (Softacort, Laboratories Thea, France) for 12 days four times daily followed by 2 days twice...” PMID 31741283 Nov 2019
413

“Pre-emptive skin treatment included a skin moisturizer (eg, Lubriderm), sunscreen (free of paraaminobenzoic acid (PABA), skin protection factor (SPF) 15 or higher,...” NCT00332163

“Patients were randomly assigned in a 1:1 ratio to either replace prednisone with 20 mg/day of hydrocortisone for 3 months, then reduce to 10 mg/day for 3 months before...” PMID 39874233 Jan 2025

“Intrathecal administration of 2nd, 3rd, and 4th doses of methotrexate 15 mg and hydrocortisone 50mg on day 2 or 3 of 2nd, 3rd, and 4th cycles of immunochemotherapy with...” NCT03123718

“Intrathecal chemotherapy will consist of either single-agent cytarabine or methotrexate, or a combination of methotrexate, cytarabine, and hydrocortisone, at appropriate...” NCT04029688

“Recommended TCS include triamcinolone acetonide 0.1% cream or fluocinolone acetonide 0.025% ointment as medium potency topical corticosteroids and hydrocortisone 1% cream as...” NCT03568318

“Patients received bisoprolol as group (A) in addition hydrocortisone 100 mg intravenously is given in the evening of the operation and then 100 mg every eight hours during the...” NCT03800264

“Agents for intrathecal (IT) chemotherapy, central nervous system (CNS)-1/2: IT methotrexate chemotherapy, or CNS-3: triple intrathecal (ITT) methotrexate, hydrocortisone, cytarabine.” NCT04501614

“This first ever study in patients with CAH is a pharmacokinetic/pharmacodynamic study comparing Chronocort to Cortef, the conventional immediate-release form of hydrocortisone.” NCT00519818

hydrocortisone 1% cream (HCT) was applied twice daily for 4 weeks on one side of forehead skin without clinical signs of AD and pimecrolimus 1% cream (PIM) on the other.” PMID 21771098 Jul 2011

“Treatment A is 10 mg hydrocortisone (2 tablets Cortef, 5 mg each),Stress-dose will be taken per os one time 2 tablets 10 mg of Cortef 60 min before start of exercise.” NCT01847690

“Chronocort® is a patented oral modified release formulation of hydrocortisone which is intended to mimic, or closely match, the serum levels of endogenous cortisol.” NCT02716818

“Bicalutamide 50 mg qd for one week, inject goserelin 10.8 mg (3-month depot), begin dutasteride 3.5 mg qd and ketoconazole 200 mg tid (with hydrocortisone 30 mg).” NCT00298155

“Methotrexate, hydrocortisone and cytarabine are combined into one preparation for intrathecal administration at multiple time points during treatment.” NCT07059975

Hydrocortisone retention enema (Cortenema) administered rectally as a single dose; each dose unit delivers 100 mg of hydrocortisone per 60 mL.” NCT02671058

“Atrophic subtype support may include: estradiol, progesterone, testosterone, DHEA, pregnenolone, levothyroxine, liothyronine, hydrocortisone.” NCT05894954

“receiving intravenous Vitamin C (1.5 g every 6 hours), Thiamine (200 mg every 12 hours) and Hydrocortisone (50 mg every 6 hours) for 7 days” NCT05192213

“Infacort® is a dry granule formulation of hydrocortisone stored in capsules available in different strengths (0.5, 1.0, 2.0 and 5.0 mg).” NCT02733367

“In each stratum, patients will be randomly assigned to receive a 7-day course of hydrocortisone and fludrocortisone or their placebos.” PMID 36898751 Mar 2023

“Methotrexate, Cytarabine and Hydrocortisone given Intrathecally on day 8, 15 and 22 for patients who are CNS 3 at study entry.” NCT00928200

“ME-609 (Xerese, Xerclear) is a combination of 5% acyclovir and 1% hydrocortisone developed for the topical treatment of HSL.” PMID 20851499 Sep 2010

“Chronocort (hydrocortisone modified-release hard capsule) supplied as 5 mg and 10 mg strengths will be administered orally.” NCT05222152

Hydrocortisone:For septic ARDS patients, 50 mg of hydrocortisone was given as an intravenous bolus every 6 hours for 7 days” NCT05658692

“In the last week of treatment, subjects will receive 90 mg/day of oral hydrocortisone or a placebo for 4 consecutive days.” NCT00220454

“Mix: Methotrexate 8-12 milligrams, Hydrocortisone 16-24 milligrams and Cytarabine 24-36 milligrams, intrathecal, day 19” NCT02451774

Hydrocortisone or hydrocortisone/hydrocortisone acetate administered via intramuscular injection as rescue medication.” NCT06979596

“Other forms of corticosteroids are also acceptable e.g. hydrocortisone, methylprednisolone at the equivalent dosage.” NCT06446245

“corticosteroids such as dexamethasone, prednisone, methylprednisolone or hydrocortisone may be administered as SOC.” NCT04843761

“intra-vesical: DMSO 50% in 50 cc water for injection 10 cc heparin 5000 IU hydrocortisone 100 mg bupivacaine 0.125%” NCT01074567

“corticosteroids such as dexamethasone, prednisone, methylprednisolone or hydrocortisone may be administered as SOC.” NCT06729593

“corticosteroids such as dexamethasone, prednisone, methylprednisolone or hydrocortisone may be administered as SOC.” NCT06729606

“IT: Methotrexate +/- prednisone/hydrocortisone/cytarabine according to the degree of central nervous involvement” NCT05745714

“IT: Methotrexate +/- prednisone/hydrocortisone/cytarabine according to the degree of central nervous involvement” NCT07175415

“IT: Methotrexate +/- prednisone/hydrocortisone/cytarabine according to the degree of central nervous involvement” NCT05658640

“IT: Methotrexate +/- prednisone/hydrocortisone/cytarabine according to the degree of central nervous involvement” NCT05751044

“IT: Methotrexate +/- prednisone/hydrocortisone/cytarabine according to the degree of central nervous involvement” NCT05740449

“Intravenous steroids were started with methylprednisolone 60 mg/d or hydrocortisone 400 mg/d for 3 days.” NCT02922374

“Patients in Arm 1 will randomized to receive usual care + hydrocortisone, thiamine and ascorbic acid.” NCT04134403

“Patients will be randomized to receive either hydrocortisone 50 mg IV every six hours for seven days” NCT00842933

“replacing the intrathecal methotrexate to intrathecal cytarabine, methotrexate and hydrocortisone.” NCT02339350

“triple intrathecal therapy (TIT) (Methotrexate [MTX]: 12 mg, ARA-C: 30 mg, hydrocortisone: 20 mg).” NCT02776605

hydrocortisone, ascorbic acid (vitamin C), and thiamine (vitamin B1); referred to as HAT” NCT05157360

Hydrocortisone (dose range 10 to 30) mg will be continued as before entering the study.” NCT02277587

“An 8 ml of hydrocortisone will be injected in the ME through posteroinferior part of TM” NCT05112354

hydrocortisone (200 mg IV) will be administered immediately prior to each infusion.” NCT03635957

“Over-encapsulated hydrocortisone modified-release capsule for oral administration.” NCT05063994

“TCS cream (triamcenolone acetonide 0.1% or hydrocortisone 2.5% cream) twice daily” NCT02340234

“5% hydroquinone, 0.003% tretinoin, and 1% hydrocortisone twice daily for 2 months” NCT05710068

Hydrocortisone hemisuccinate 50 mg: one intravenous injection every 6 hours” NCT04404400

“Immediate release multiparticulate formulation (granules) of hydrocortisoneNCT03311932

“single dose of 20mg modified release hydrocortisone in the absence of food” NCT02408068

Hydrocortisone, 100 mg IV shall be given immediately at start of treatment” NCT01091337

Hydrocortisone intravenous: 100mg hydrocortisone as sodium succinate i.v.” NCT07262957

“IT cytarabine, methotrexate, and either prednisolone or hydrocortisoneNCT03793478

“Oral administration of Hydrocortisone will increase HPA axis activity.” NCT02372110

“Methotrexate 12 mg IT, Hydrocortisone 24mg IT, Cytarabine 36mg IT” NCT05192889

“Immediate-release multiparticulate formulation of hydrocortisone.” NCT03178214

“methotrexate (12 mg) cytarabine (30 mg) hydrocortisone (20 mg)” NCT00466258

Hydrocortisone modified release capsules - 5mg, 10mg and 20mg.” NCT03532022

“Postoperative administration of hydrocortisone for one month” NCT07558811

“Idroflog® (0.2% Hyaluronic Acid with 0.001% Hydrocortisone)” NCT06576245

“100mg of Hydrocortisone will be injected In the peritoneum” NCT03845608

“Yohimbine hydrochloride 60mg + Hydrocortisone 20mg tablet” NCT03015246

Hydrocortisone 200mg continuous intravenous infusion(24h)” NCT03821714

“conventional GCs (cortisone acetate or hydrocortisone)” PMID 39171906 Aug 2024

Hydrocortisone modified-release capsule 5 mg and 10 mg” NCT05299554

“Cortef® Immediate Release Hydrocortisone Tablets” NCT03343327

“once-daily, modified-release oral hydrocortisonePMID 29229498 Dec 2017

“Perioperative Hydrocortisone Reduction Therapy” NCT06679816

“intravenous hydrocortisone 80 mg twice daily” NCT04381936

“ME-609 (5% acyclovir and 1% hydrocortisone)” NCT00735761

“dry granule formulation of hydrocortisoneNCT02720952

“methotrexate/hydrocortisone/cytarabine” NCT02676323

“Methotrexate/hydrocortisone/cytarabine” NCT02553460

“Methotrexate/hydrocortisone/cytarabine” NCT02433483

“methotrexate/hydrocortisone/cytarabine” NCT05656248

“methotrexate/hydrocortisone/cytarabine” NCT06177067

Hydrocortisone, Vitamin C and Thiamine” NCT03380507

“methotrexate/hydrocortisone/cytarabine” NCT03515200

“Methotrexate/Hydrocortisone/Cytarabine” NCT03164057

“methotrexate/hydrocortisone/cytarabine” NCT03194932

“Modified formulation of hydrocortisoneNCT03051893

“20 mg of Depomedrol (hydrocortisone)” NCT02417987

“Physical cooling,HydrocortisoneNCT01973855

“* hydrocortisone 2.5%” NCT01313221

Hydrocortisone cream” NCT00980135

“A: hydrocortisoneNCT02552251

Hydrocortisone:” NCT00440726

HydrocortisoneNCT02716818

hydrocortisoneNCT01941589

NCT00625209

NCT01007591

NCT03261336

NCT02473263

NCT00773058

NCT00805285

NCT01859312

NCT04597762

NCT00136435

NCT01104025

NCT03465007

NCT00049569

NCT00704262

NCT00172354

NCT01860664

NCT07558135

NCT04197115

NCT02552654

NCT00709839

NCT03792256

NCT02517489

NCT05160506

NCT00358748

NCT03832010

NCT00460031

NCT01450930

NCT00186628

NCT05974410

NCT04137302

NCT03302416

NCT01095172

NCT03258684

NCT00676585

NCT03509350

NCT01828515

NCT01063569

NCT02212561

NCT00133991

NCT00482053

NCT06895473

NCT05324618

NCT00675272

NCT00186264

NCT00019409

NCT03585829

NCT00354107

NCT00002700

NCT01574612

NCT02790788

NCT01265017

NCT00855270

NCT01867294

NCT02722200

NCT02152553

NCT07703098

NCT00623740

NCT00536991

NCT03142893

NCT02760862

NCT07494084

NCT02419755

NCT00002704

NCT00859781

NCT03649009

NCT00004669

NCT00309894

NCT02256865

NCT03773822

NCT07313670

NCT01047670

NCT05292664

NCT01771328

NCT06435481

NCT04465539

NCT03371784

NCT03913559

NCT03649633

NCT00623766

NCT02425852

NCT03682393

NCT05193396

NCT00396344

NCT01574014

NCT00181597

NCT05674253

NCT01093261

NCT00270777

NCT00621985

NCT03670212

NCT01036594

NCT00899847

NCT01064986

NCT06430580

NCT00915343

NCT07383103

NCT06390319

NCT02481310

NCT04231708

NCT05716607

NCT06892197

NCT07037043

NCT04435912

NCT00451230

NCT00131053

NCT02303821

NCT05761171

NCT04037605

NCT00003436

NCT06892210

NCT01595386

NCT00705822

NCT01451515

NCT00149123

NCT00933023

NCT00002744

NCT02090309

NCT03062280

NCT00002756

NCT02282150

NCT00002757

NCT04621565

NCT02112019

NCT02402114

NCT03813147

NCT00002760

NCT04039815

NCT06260462

NCT01301677

NCT06381661

NCT01150409

NCT05049473

NCT01448109

NCT04348305

NCT05159284

NCT01005758

NCT01399268

NCT07387926

NCT00185692

NCT04180969

NCT00002471

NCT03760835

NCT00670254

NCT01186328

NCT00490828

NCT00853008

NCT02756546

NCT04898894

NCT06723626

NCT04492280

NCT06104449

NCT00003728

NCT02602210

NCT03872011

NCT05276323

NCT01954056

NCT02523664

NCT00640822

NCT01546922

NCT00003215

NCT00953576

NCT05919992

NCT06136650

NCT06018727

NCT02768740

NCT06136624

NCT06136598

NCT04293562

NCT01156480

NCT00674570

NCT07248761

NCT02465606

NCT00732277

NCT02360046

NCT00236925

NCT02691858

NCT05476770

NCT03071276

NCT05139849

NCT01014364

NCT05354778

NCT04896489

NCT02837432

NCT05457296

NCT00706173

NCT00320099

NCT02735707

NCT00368381

NCT00895310

NCT05607901

NCT04148261

NCT06496997

NCT03936517

NCT05818826

NCT00590018

NCT03592693

NCT00165178

NCT00688987

NCT00027859

NCT02714543

NCT01090518

NCT06982183

NCT00002805

NCT04536662

NCT00559481

NCT03349281

NCT04359511

NCT04359147

NCT00415701

NCT03389555

NCT00147004

NCT03718234

NCT07695337

NCT04591990

NCT00618501

NCT00691002

NCT00591006

NCT02044159

NCT07154849

NCT07332325

NCT00980876

NCT00392834

NCT00006455

NCT03910088

NCT01614197

NCT03286634

NCT00874393

NCT04821583

NCT00097474

NCT02700828

NCT02266264

NCT00673127

NCT05836610

NCT00694408

NCT07072585

NCT03548246

NCT03817320

NCT04181515

NCT00002865

NCT04160676

NCT00006371

NCT03422159

NCT01353313

NCT00597857

NCT04082533

NCT01422707

NCT01089075

NCT04852458

NCT00375713

NCT03896659

NCT01422733

NCT02190994

NCT06217939

NCT01735617

NCT06942039

NCT05008146

NCT01460615

NCT00473083

NCT01108146

NCT00673270

NCT00176462

NCT02580240

NCT02043587

NCT04508946

NCT02229136

NCT04325490

NCT02266589

NCT01559675

NCT01070225

NCT00507832

NCT00442494

NCT03710187

NCT06930456

NCT02084134

NCT00002881

NCT01960530

NCT03333278

NCT03237689

NCT06556277

NCT04536129

NCT00563303

NCT01782859

NCT01815918

NCT03401398

NCT05350020

NCT04924166

NCT02535806

NCT03020030

NCT07686107

NCT02230930

NCT05816226

NCT06504160

NCT05436535

NCT03282487

NCT06289673

NCT01108133

NCT02777268

NCT00002494

NCT02289989

NCT04456439

NCT02270788

NCT00002921

NCT03748537

NCT01284452

NCT00002970

NCT07612631

NCT04615962

NCT00001521

NCT03019614

NCT02775227

NCT01769339

NCT00862381

NCT01453686

NCT00167544

NCT00751855

NCT00442390

NCT03335124

NCT05435781

NCT00657306

NCT02114710

NCT00526305

NCT05668455

NCT05167084

NCT00729794

NCT00334672

Known as 17-Hydroxycorticosterone “Hydrocortisone (17-Hydroxycorticosterone) is the preferred cortisol replacement.” NCT06435481
Known as Chronocort Chronocort (hydrocortisone modified-release hard gelatin capsules for oral administration - 5mg and 10mg” NCT05222152
1

Chronocort® modified release hydrocortisone” NCT03062280

Known as Cortef “This was a two-part, single centre, open-label, randomised, single dose, two-period, crossover study to evaluate the bioavailability of Infacort® versus Cortef® immediate...” NCT03311932
4

“Hydrocortisone (Cortef™) 20mg tablet administered on one day.” NCT03015246

Cortef (hydrocortisone)” NCT01063569

NCT00519818

NCT03343327

Known as Cortenema “Hydrocortisone retention enema (Cortenema) administered rectally as a single dose; each dose unit delivers 100 mg of hydrocortisone per 60 mL.” NCT02671058
Known as Corticosteroid ClinicalTrials.gov intervention name — accepted as the source's own label NCT07536399
1

NCT02056418

Known as cortisol “This study will examine the effects of cortisol (hydrocortisone), melatonin, a combination of cortisol and melatonin, and placebo (an inactive substance) on jet lag symptoms.” NCT00097474
9

“Hydrocortisone is the pharmaceutical term for cortisol, the principal glucocorticoid secreted by the adrenal gland” NCT02700828

“intravenous hydrocortisone (cortisol) challenge” NCT03302416

NCT00759005

NCT00451750

NCT00362661

NCT03558971

NCT01718964

NCT02196142

NCT04921189

Known as CORTIVIS “Hydrocortisone (CORTIVIS ®)” NCT04536129
Known as DF277 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01395966
1

NCT01996748

Known as HCT “hydrocortisone 1% cream (HCT) was applied twice daily for 4 weeks on one side of forehead skin without clinical signs of AD and pimecrolimus 1% cream (PIM) on the other.” PMID 21771098 Jul 2011
Known as High Volume injection ClinicalTrials.gov intervention name — accepted as the source's own label NCT02417987
Known as Hy-Cortisone Injection “single dose Hy-Cortisone Injection 250 mg (Generic name: Hydrocortisone Sodium Succinate, Cirin Pharmaceuticals Pakistan) intramuscularly after extraction” NCT06637384
Known as Hydrocortison ClinicalTrials.gov intervention name — accepted as the source's own label NCT01691209
1

NCT01228110

Known as hydrocortisone acetate “This cream consists of lidocaine (5% w/w), hydrocortisone acetate (7.5% w/w), aluminium sub-acetate (3.5% w/w), and zinc oxide (18% w/w).” NCT02301052
9

“Hydrocortisone or hydrocortisone/hydrocortisone acetate administered via intramuscular injection as rescue medication.” NCT06979596

“Anucort HC TM (Hydrocortisone Acetate) 25mg Rectal Suppositories” NCT01913158

NCT07124650

NCT03358082

NCT02671058

NCT04469686

NCT00801957

NCT02689856

NCT03335774

Known as Hydrocortisone hemisuccinate Hydrocortisone hemisuccinate (Hydrocortisone Upjohn) was supplied as a powder in 100 mg vials to be reconstituted with 2 ml of sterile water diluent.” NCT02768740
3

HYDROCORTISONE HEMISUCCINATE Vials with lyophilisate (100mg hydrocortisone) are provided by SERB laboratory.” NCT04591990

Hydrocortisone hemisuccinate (Roussel-Uclaf, Romainville, France), 50 mg intravenously every 6 hrs” NCT02114710

Hydrocortisone hemisuccinate (Roussel-Uclaf, Romainville, France), 50 mg intravenously every 6 hrs” NCT02266589

Known as Hydrocortisone immediate release tablet Hydrocortisone immediate release tabletNCT00519818
Known as Hydrocortisone modified-release hard capsule Hydrocortisone modified-release hard capsuleNCT05299554
Known as Hydrocortisone sodium acetate ClinicalTrials.gov intervention name — accepted as the source's own label NCT00529841
Known as Hydrocortisone Sodium Succinate “The Children's Cancer Group (CCG) 1952 clinical trial for children with standard-risk acute lymphoblastic leukemia (SR-ALL) compared intrathecal (IT) methotrexate (MTX) with IT...” PMID 16609069 Apr 2006
17

Hydrocortisone sodium succinate for intravenous administration (unpreserved, Solu-Cortef plain, Pfizer®, reconstituted with unpreserved normal saline to avoid exposure to the...” NCT01353313

“hydrocortisone (hydrocortisone sodium succinate, plain; will not have benzyl alcohol)” NCT01954056

“Generic name: Hydrocortisone Sodium Succinate, Cirin Pharmaceuticals Pakistan” NCT06637384

“* Hydrocortisone sodium succinate (Solucortef) 100 mg” NCT00317070

“Drug: Hydrocortisone Sodium SuccinateNCT05761171

NCT06247787

NCT04546399

NCT04301479

NCT03110198

NCT05320380

NCT02828358

NCT02112916

NCT00720109

NCT00057811

NCT00476190

NCT02883049

NCT06122987

Known as Hydrocortisone Upjohn “Hydrocortisone hemisuccinate (Hydrocortisone Upjohn) was supplied as a powder in 100 mg vials to be reconstituted with 2 ml of sterile water diluent.” NCT02768740
Known as Hydrocortisone-21-acetate Hydrocortisone-21-acetate creme (25%) 15 microl/cm2 b.i.d.” NCT01055249
Known as Infacort “This was a two-part, single centre, open-label, randomised, single dose, two-period, crossover study to evaluate the bioavailability of Infacort® versus Cortef® immediate...” NCT03311932
2

Infacort® is a dry granule formulation of hydrocortisone stored in capsules that will be available in different strengths (0.5, 1.0, 2.0 and 5.0mg).” NCT02720952

Infacort® is a dry granule formulation of hydrocortisone stored in capsules available in different strengths (0.5, 1.0, 2.0 and 5.0 mg).” NCT02733367

Known as Intrathecal Triples ClinicalTrials.gov intervention name — accepted as the source's own label NCT02518750
Known as LDH “low dose hydrocortisone (LDH)” NCT03237689
Known as MR-HC “modified-release hydrocortisone (MR-HC), which mimics physiologic cortisol secretion” PMID 33527139 Apr 2021