drugset / Trial / NCT04134403
Steroids, Thiamine and Ascorbic Acid in Septic Shock
Phase 3
Unknown
80 enrolled
Baqiyatallah Medical Sciences University
Hamadan University of Medical Science · collabTehran University of Medical Sciences · collab
RandomizedParallel-groupQuadruple-blindTreatment
Summary
The objective of this project is to determine if in patients admitted to the hospital with septic shock (population), does treatment with a bundle including hydrocortisone, thiamine, and ascorbic acid improve in-hospital or 28-day mortality (primary outcomes) or surrogate markers of illness severity including: (1) ICU or hospital length-of-stay, (2) duration of invasive mechanical ventilation, (3) duration of vasopressor administration, (4) incidence and severity of ICU delirium, and (5) illness severity (secondary outcomes).
Timeline
- Start
- 2019-12-01
- Primary completion
- 2020-11-01
- Completion
- 2020-12-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Hydrocortisone | Other / unclassified | 50 mg | — |
| Subject | Thiamine | Other / unclassified | 200 mg | — |
| Subject | Vitamin C | Other / unclassified | 1500 mg | — |