Thiamine
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | BEROCCA PN | — | 1947-07-28 | fda.gov ↗ |
Trials 65 · started per year
News releases announcing trial results or a regulatory action · 1
| Date | Issuer | Release |
|---|---|---|
| 2020-05-20 | KRKA | Regulatory Krka Reports First Quarter 2020 Business Results krka.biz ↗
We extended our range of non-prescription products with a marketing authorisation for our new formulation of B-complex (thiamine/riboflavin/pyridoxine/cyanocobalamin/calcium pantothenate/nicotinamide) film-coated tablets. |
All press releases naming this drug 1 release
| Date | Issuer | Release |
|---|---|---|
| 2020-05-20 | KRKA | Krka Reports First Quarter 2020 Business Results krka.biz ↗ |
Evidence & citations 14 cited values
Every value below carries the sentence it was read from. 88 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | thiamine | “Active drug comprised of: ascorbic acid, magnesium sulfate heptahydrate, cyanocobalamin, thiamine, riboflavin 5' phosphate, niacinamide, pyridoxine, calcium d-pantothenate, and...” NCT04708340 ↗65“Each tablet contains 4 active ingredients as follows: Alpha lipoic acid 300mg, Vitamin B12 (methylcobalamin) 500mcg, Vitamin B6 (pyridoxine) 8mg, Vitamin B1 (thiamine) 39mg.” NCT06568185 ↗ “gabapentin (GBP) plus complex B vitamins: thiamine (B1) and cyanocobalamine (B12) compared to pregabalin in patients with moderate to severe intensity PDN.” PMID 26885528 ↗ Jan 2016 “intravenous Thiamine (200mg in 50 mL of 0.9% normal saline and was administered as a 30-min infusion every 12 hours for 4 days or until ICU discharge)” NCT04039815 ↗ “and thiamine (200 mg every 12 hours administered as an infusion over 30 to 60 minutes and mixed in a 100-mL solution of normal saline) for 3 days.” NCT06152458 ↗ “Complex B ((Thiamine 100mg, Pyridoxine 5 mg and Cyanocobalamin 50 mcg) 1 tablet enteral route every 6 horas for 4 days or until ICU discharge” NCT04197115 ↗ “Patients were assigned randomly to receive thiamine (300 mg in 0.9% Normal saline solution) or placebo (0.9% Normal saline) preoperatively.” PMID 26066773 ↗ Aug 2015 “receiving intravenous Vitamin C (1.5 g every 6 hours), Thiamine (200 mg every 12 hours) and Hydrocortisone (50 mg every 6 hours) for 7 days” NCT05192213 ↗ “In addition, all patients will receive intravenous thiamine 200 mg twice a day for 3 days to limit the oxalate production.” NCT05817851 ↗ “Dosage: 25 mg of Dexketoprofen + Cyanocobalamin 500 µg, Thiamine 100 mg, Pyridoxine 50 mg. Administration way: oral” NCT05027126 ↗ “MGO cocktail containing a combination of alpha-lipoic acid, nicotinamide, thiamine, pyridoxamine, and piperine” NCT05083546 ↗ |
| Known as | Bevitine | “Vitamin C (Laroscorbine) + Vitamin B1 (Bevitine)” NCT05817851 ↗ |
| Known as | Thiamin | “Thiamine (vitamin B1) is a water-soluble vitamin and is involved in several stages of intermediate metabolism which are important for producing energy.” NCT01524315 ↗3“Thiamin one tablet daily provides 50 milligrams(mg) of thiamin, Vitamin B-50 one tablet daily: provides an additional 50 mg of thiamin” NCT01474486 ↗ |
| Known as | Thiamine HNO3 | “Vitamin B1 (Thiamine HNO3): 1.5 mg” NCT00064753 ↗ |
| Known as | Thiamine hydrochloride | “Thiamine hydrochloride (vitamin B1) 500mg IV will be given every 12 hours for 5 doses in the experimental arm.” NCT03450707 ↗ |
| Known as | Thiamine Hydrocloride | “Patients in this arm will receive a solution of 500 mg of Thiamine Hydrocloride in a solution of 100 ml of NaCl 0.9%.” NCT04641104 ↗ |
| Known as | Thiamine Mononitrate | “Thiamine (thiamine mononitrate) - 10 mg” NCT07592897 ↗1“Drug: Thiamine Mononitrate” NCT03989700 ↗ |
| Known as | Thiamine: brand name: Thiamine Hakim | “Thiamine: brand name: Thiamine Hakim” NCT01115504 ↗ |
| Known as | Vitamin B1 | “A small retrospective study demonstrated a mortality benefit by using high dose vitamin C, thiamine (vitamin B1), and hydrocortisone (Triple therapy) for treatment of septic...” NCT04508946 ↗26“Thiamine (Vitamin B1) is essential for cell function and as a co-factor of the enzyme Pyruvate Dehydrogenase to initiate the Krebs cycle and thus the aerobic metabolism of glucose.” NCT04641104 ↗ “Deficiencies in thiamine (vitamin B1) and riboflavin (vitamin B2) have been implicated as cofactors in producing hyperlactatemia and lactic acidosis in NRTI-treated patients.” NCT00031057 ↗ “Each tablet contains 4 active ingredients as follows: Alpha lipoic acid 300mg, Vitamin B12 (methylcobalamin) 500mcg, Vitamin B6 (pyridoxine) 8mg, Vitamin B1 (thiamine) 39mg.” NCT06568185 ↗ “Each capsule is a combination of vitamins and natural products: Vitamin B1 (100mg); Vitamin B6 (50mg); Niacin (200mg); Alpha Lipoic Acid (150mg); and Piperine (15mg).” NCT06242535 ↗ “Thiamine (vitamin B1) is a water-soluble vitamin and is involved in several stages of intermediate metabolism which are important for producing energy.” NCT01524315 ↗ “This study will examine the effect of oral thiamine (Vitamin B1) supplementation on pain in patients with diabetic peripheral neuropathy.” NCT00279266 ↗ “vitamin B1 (100mg) will be diluted in 50 ml 0.9% NACL(normal saline) and administered IV every 6 hours for 3 days” NCT05663164 ↗ “Glucocorticoid combination therapy is defined as the combination of hydrocortisone, vitamin C, and vitamin B1.” NCT03821714 ↗ “Supplementation of thiamine (vitamin b1) 300 mg per day, once daily, for a duration of 4 weeks” NCT00770107 ↗ “hydrocortisone, ascorbic acid (vitamin C), and thiamine (vitamin B1); referred to as HAT” NCT05157360 ↗ |
| Known as | Vitamin B1 or Thiamin or Thiamine or Aneurin | “Vitamin B1 or Thiamin or Thiamine or Aneurin” NCT02087462 ↗ |
| Known as | Vitamin B1-injektopas | “thiamine (Vitamin B1-injektopas®, Ampoule, Germany, 100 mg / 2 ml) 200 mg diluted in 10 ml normal saline IV /12 h” NCT04160676 ↗ |
| Action | Activate | “Thiamine (vitamin B1) is a key co-factor for PDH function and will increase activity even in non-deficient states.” NCT02322892 ↗ |
| Modality | Other / unclassified | “combination of AOX micronutrient supplements” NCT00515736 ↗ |
| Route | Oral | “every patient receives high-dose oral vitamin B1 and B2 therapy for 4 weeks.” NCT00031057 ↗ |