drugset / Trial / NCT00861523

Does Thiamine Help Vomiting and Nausea in Pregnancy?

NCT00861523

Phase 3 Terminated 50 enrolled HaEmek Medical Center, Israel
RandomizedCrossoverOpen-labelTreatment

Summary

There are different treatments for nausea and vomiting in pregnancy. According to the ACOG recommendations, promethazine is the first line of parenteral treatment after oral treatment had failed. Thiamine is given to prevent wernicke encephalopathy. This research try to find out whether thiamine helps the vomiting and nausea as well, by comparing the response to thiamine and promethazine in women who suffer from nausea and vomiting in pregnancy.

Timeline

Start
2009-02
Primary completion
2012-01
Completion
2012-01

Drugs

EvaluationDrugModalityDoseRoute
Comparator Promethazine Small molecule 25 mg Intravenous
Comparator Thiamine Other / unclassified 100 mg Intravenous