drugset / Trial / NCT04921189
Steroid, Thiamine and Ascorbic Acid for Comatose Out-of-hospital Cardiac Arrest Survivors
Phase 2
Completed
160 enrolled
Asan Medical Center
Chung-Ang University · collabEwha Womans University · collabHanil General Hospital · collabHanyang University · collabSamsung Changwon Hospital · collabSamsung Medical Center · collabSeoul St. Mary's Hospital · collabWonju Severance Christian Hospital · collab
RandomizedParallel-groupDouble-blindTreatment
Summary
The mortality and neurological outcomes among out-of-hospital cardiac arrest survivors have not improved despite the medical advances. The whole body ischemia/reperfusion injuries after cardiac arrest mainly damaged the brain. To improve the neurologic outcome among those patients, additional interventions would be warranted. The investigators hypothesize that the combined use of cortisol, ascorbic acid (vitamin C), and thiamine during the early post-resuscitation period would attenuate the whole-body ischemia/reperfusion injuries among the out-of-hospital cardiac arrest survivors treated with targeted temperature management.
Timeline
- Start
- 2021-12-31
- Primary completion
- 2024-12-10
- Completion
- 2025-06-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Hydrocortisone | Other / unclassified | 100 mg | Intravenous |
| Comparator | Thiamine | Other / unclassified | 200 mg | Intravenous |
| Comparator | Vitamin C | Other / unclassified | 50 mg/kg | Intravenous |