Vitamin C, Thiamine and Hydrocortisone for the Treatment of Septic Shock

NCT03872011 ↗

Phase 3 Completed 408 enrolled Northern Jiangsu People's Hospital

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to determine whether the combination therapy (vitamin C,thiamine and hydrocortisone) is effective in the treatment of septic shock.

Timeline

Start: 2019-02-19
Primary completion: 2021-09-20
Completion: 2021-09-20

Outcome

Missed primary endpoint

paper the primary outcome of 90-day mortality was 39.9% (81/203) and 39.0% (80/205) in the intervention and the placebo groups, respectively, and was not significantly different PMID 36171582 ↗

Publications

Lyu QQ, Zheng RQ, Chen QH, Yu JQ, Shao J, Gu XH. Early administration of hydrocortisone, vitamin C, and thiamine in adult patients with septic shock: a randomized controlled clinical trial. Crit Care. 2022 Sep 28;26(1):295. doi: 10.1186/s13054-022-04175-x.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Hydrocortisone	Other / unclassified	200 mg	Intravenous
Subject	Thiamine	Other / unclassified	200 mg	Intravenous
Subject	Vitamin C	Other / unclassified	2 g	Intravenous