The Effect of Thiamine vs. Placebo on VO2 in Critical Illness

Summary

The objective of this study is to determine the effect of thiamine therapy on oxygen consumption (VO2) in critically-ill patients. We will evaluate this by measuring VO2 before and after thiamine or placebo administration in patients admitted to the ICU and requiring mechanical ventilation. A secondary aim is to evaluate the effect of thiamine vs. placebo on the metabolic profile of the patients.

Timeline

Start

2013-10

Primary completion

2016-05

Completion

2016-12

Drugs

Indications