Thiamine as a Metabolic Resuscitator in Septic Shock

Phase 1/2 Completed 88 enrolled Beth Israel Deaconess Medical Center National Center for Complementary and Integrative Health (NCCIH) · collab National Institutes of Health (NIH) · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

The major goal of this project is to determine whether the use of thiamine in patients with septic shock will result in attenuation of lactic acidosis and a more rapid reversal of shock.

Timeline

Start: 2010-02
Primary completion: 2014-11
Completion: 2014-11

Publications

Vine J, Lee JH, Kravitz MS, Grossestreuer AV, Balaji L, Leland SB, Berlin N, Moskowitz A, Donnino MW. Thiamine administration in septic shock: a post hoc analysis of two randomized trials. Crit Care. 2024 Feb 6;28(1):41. doi: 10.1186/s13054-024-04818-1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Thiamine	Other / unclassified	200 mg	—

Thiamine as a Metabolic Resuscitator in Septic Shock

Summary

Timeline

Publications

Drugs

Indications