drugset / Trial / NCT03142893
Hormonal Mechanisms of Sleep Restriction - Axis Study
RandomizedCrossoverTriple-blindBasic science
Summary
The purpose of this study is to 1) determine how hypothalamic-pituitary-adrenal axis (HPA axis) activation occurs with sleep restriction 2) evaluate how hypothalamic-pituitary-gonadal axis (HPG axis) deactivation occurs with sleep restriction. The investigator will also examine the cognitive function associated with sleep restriction, including food intake and food cravings.
Timeline
- Start
- 2017-05-08
- Primary completion
- 2020-10-30
- Completion
- 2026-06-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cosyntropin | Unknown | — | — |
| Subject | Dexamethasone | Small molecule | — | Oral |
| Subject | Dexamethasone | Small molecule | — | Intravenous |
| Subject | Ganirelix | Protein / enzyme biologic | — | Subcutaneous |
| Subject | Gonadorelin | Protein / enzyme biologic | — | Intravenous |
| Subject | Hydrocortisone | Other / unclassified | — | Intravenous |
| Subject | Ketoconazole | Small molecule | — | — |
| Subject | Recombinant Human Luteinizing Hormone | Protein / enzyme biologic | — | Intravenous |
| Subject | Xerecept | Unknown | — | Intravenous |
Indications
No indication recorded.