Drugs / Gonadorelin
Gonadorelin
also known as
GnRH · gonadotropin-releasing hormone · gonadorelin acetate · ABBOTT-41070 · AY-24,031 · Factrel · Fertagyl · Fertiral lh-rh · +19 more
Protein / enzyme biologic targets GNRHR via activation
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | FACTREL | — | 1982-09-30 | fda.gov ↗ |
Trials 20 · a red edge is where a trial was stopped
Also used as a comparator or background therapy in 5 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 01 trial | ||||||
| Phase 0 | NCT04037605 Background | Feb 2020 → Jul 2022 overdue | — | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Active not recruiting | No outcome recorded |
| Phase 11 trial | ||||||
| Phase 1 | NCT00431197 Background | Feb 2004 → Dec 2007 | hypogonadism | Mayo Clinic | Completed | No outcome recorded |
| Phase 22 trials | ||||||
| Phase 2 | NCT04648969 Background | May 2019 → Aug 2025 | hypogonadotropic hypogonadism | Massachusetts General Hospital | Completed | No outcome recorded |
| Phase 2 | NCT00064987 Background | Apr 2001 → Oct 2012 | Kallmann syndrome | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Terminated | No outcome recorded |
| Phase 2/31 trial | ||||||
| Phase 2/3 | NCT04390646 Comparator | Aug 2020 → Dec 2028 expected | Down syndrome, early-onset autosomal dominant Alzheimer disease, olfactory nerve disorder | Nelly Pitteloud | Recruiting | No outcome recorded |
Evidence & citations 33 cited values
Every value below carries the sentence it was read from. 29 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Gonadorelin | “pulse infusion of gonadorelin via micropump” PMID 25131486 ↗ Aug 2014 |
| Known as | ABBOTT-41070 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1007 ↗ |
| Known as | AY-24,031 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1007 ↗ |
| Known as | Factrel | ChEMBL registry synonym — accepted as the source's own label CHEMBL1007 ↗ |
| Known as | Fertagyl | ChEMBL registry synonym — accepted as the source's own label CHEMBL1007 ↗ |
| Known as | Fertiral lh-rh | ChEMBL registry synonym — accepted as the source's own label CHEMBL1007 ↗ |
| Known as | GnRH | “pulsatile GnRH therapy in IHH men is very successful in inducing androgen production and spermatogenesis” PMID 12213860 ↗ Sep 200214“gonadotropin releasing hormone (GnRH)” NCT00493961 ↗ “gonadotropin releasing hormone (GnRH)” NCT00064987 ↗ |
| Known as | gonadorelin acetate | “GnRH, gonadorelin acetate” NCT04390646 ↗ |
| Known as | Gonadorelin acetate anhydrous | ChEMBL registry synonym — accepted as the source's own label CHEMBL1007 ↗ |
| Known as | Gonadorelin acetate mixture | ChEMBL registry synonym — accepted as the source's own label CHEMBL1007 ↗ |
| Known as | Gonadorelin decapeptide | ChEMBL registry synonym — accepted as the source's own label CHEMBL1007 ↗ |
| Known as | Gonadorelin hcl | ChEMBL registry synonym — accepted as the source's own label CHEMBL1007 ↗ |
| Known as | GONADORELIN HYDROCHLORIDE | ChEMBL registry synonym — accepted as the source's own label CHEMBL1007 ↗ |
| Known as | Gonadorelina | ChEMBL registry synonym — accepted as the source's own label CHEMBL1007 ↗ |
| Known as | Gonadoreline | ChEMBL registry synonym — accepted as the source's own label CHEMBL1007 ↗ |
| Known as | gonadotropin-releasing hormone | “two investigational drugs, the naturally occurring hormones kisspeptin and gonadotropin-releasing hormone (GnRH)” NCT01438034 ↗6“Drug: Gonadotropin-releasing Hormone” NCT02705014 ↗ |
| Known as | Hypocrine | ChEMBL registry synonym — accepted as the source's own label CHEMBL1007 ↗ |
| Known as | Lh releasing factor | ChEMBL registry synonym — accepted as the source's own label CHEMBL1007 ↗ |
| Known as | LHRH | “Luteinizing hormone releasing hormone (LHRH)” NCT00223860 ↗ |
| Known as | Luteinizing | ChEMBL registry synonym — accepted as the source's own label CHEMBL1007 ↗ |
| Known as | Luteinizing hormone releasing hormone | ClinicalTrials.gov intervention name — accepted as the source's own label NCT00223860 ↗ |
| Known as | luteinizing hormone-releasing factor | ClinicalTrials.gov intervention name — accepted as the source's own label NCT00004330 ↗ |
| Known as | Luteinizing hormone-releasing factor diacetate tetrahydrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL1007 ↗ |
| Known as | Luteinizing hormone-releasing factor dihydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL1007 ↗ |
| Known as | Lutrelef | ChEMBL registry synonym — accepted as the source's own label CHEMBL1007 ↗ |
| Known as | Lutrepulse | “Gonadorelin (also known as Lutrepulse)” NCT04037605 ↗ |
| Known as | Lutrepulse kit | ChEMBL registry synonym — accepted as the source's own label CHEMBL1007 ↗ |
| Known as | Relefact lh-rh | ChEMBL registry synonym — accepted as the source's own label CHEMBL1007 ↗ |
| Action | Restore | “This treatment replaces the hormone which is absent in IHH” NCT00392756 ↗ |
| Modality | Peptide | “Although differences in plasma GnRH concentrations have been identified after iv and sc injection of this peptide” PMID 3900124 ↗ Nov 1985 |
| Modality | Protein / enzyme biologic | — CHEMBL1007 ↗ |
| Route | Subcutaneous | “Patients receive one subcutaneous injection of leuprolide acetate or GnRH” NCT00004426 ↗ |
| Target | GNRHR | “Pulsatile GnRH acts on the gonadotrophs via the GnRH receptor (GNRHR) in the pituitary gland” NCT04390646 ↗ |