drugset / Trial / NCT00386022
The Effects of Aging and Estrogen on the Pituitary
Phase 2/3
Unknown
19 enrolled
Massachusetts General Hospital
National Institute on Aging (NIA) · collab
RandomizedSequentialOpen-labelOther
Summary
The purpose of this study is to study the effects of aging and estrogen on the brain. Specifically, this study will examine how the hypothalamus signals the pituitary gland to secrete reproductive hormones and how that changes with aging.
Timeline
- Start
- 2002-01
- Primary completion
- 2012-01
- Completion
- 2018-01
Publications
- Results Shaw ND, Histed SN, Srouji SS, Yang J, Lee H, Hall JE. Estrogen negative feedback on gonadotropin secretion: evidence for a direct pituitary effect in women. J Clin Endocrinol Metab. 2010 Apr;95(4):1955-61. doi: 10.1210/jc.2009-2108. Epub 2010 Feb 4.
- Results Shaw ND, Srouji SS, Histed SN, McCurnin KE, Hall JE. Aging attenuates the pituitary response to gonadotropin-releasing hormone. J Clin Endocrinol Metab. 2009 Sep;94(9):3259-64. doi: 10.1210/jc.2009-0526. Epub 2009 Jun 23.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Gonadorelin | Protein / enzyme biologic | 25 ng | Intravenous |
| Subject | Gonadorelin | Protein / enzyme biologic | 75 ng | Intravenous |
| Subject | Gonadorelin | Protein / enzyme biologic | 250 ng | Intravenous |
| Subject | Gonadorelin | Protein / enzyme biologic | 750 ng | Intravenous |
| Subject | conjugated estrogens | Other / unclassified | 0.05 mg | Other |
| Background | NAL-GLU | Unknown | 150 ug/kg | Subcutaneous |
Indications
No indication recorded.