Hormonal Mechanisms of Sleep Restriction - Axis Study in Older Men and Postmenopausal Women

Phase 0 Active not recruiting 5 enrolled Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

RandomizedCrossoverTriple-blindBasic science

Summary

The purpose of this study is to 1) determine how hypothalamic-pituitary-adrenal axis (HPA axis) activation occurs with sleep restriction and 2) evaluate how hypothalamic-pituitary-gonadal axis (HPG axis) deactivation occurs with sleep restriction. The investigator will also examine the cognitive function associated with sleep restriction, including food intake and food cravings.

Timeline

Start: 2020-02-09
Primary completion: 2022-07-24
Completion: 2026-06-24

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cosyntropin	Unknown	—	Other
Subject	Dexamethasone	Small molecule	—	Oral
Subject	Ganirelix	Protein / enzyme biologic	—	Subcutaneous
Subject	Hydrocortisone	Other / unclassified	—	Intravenous
Subject	Ketoconazole	Small molecule	—	Oral
Subject	Recombinant Human Luteinizing Hormone	Protein / enzyme biologic	—	Intravenous
Background	Gonadorelin	Protein / enzyme biologic	—	Intravenous
Background	Xerecept	Unknown	—	Intravenous

Indications

No indication recorded.