Elucidating Kisspeptin Physiology by Blocking Kisspeptin Signaling

Summary

The investigators are looking for subjects to complete a study on the role of kisspeptin in the reproductive system. Kisspeptin is a naturally occurring hormone in humans that tells the body to produce other reproductive hormones. However, giving someone a continued amount of kisspeptin over a period of time can have the opposite effect and tell the body to, for a short time, stop making hormones needed for reproduction. By giving 24-hour infusions of kisspeptin, the investigators hope to learn more about the role kisspeptin has in the way bodies function normally and the role it has in conditions that affect the reproductive system.

Timeline

Start

2011-09

Primary completion

2016-04

Completion

2016-04

Publications

• Naveed A, Lippincott MF, Stamou M, Balasubramanian R, Bryant NK, Seminara SB. Dynamic modulation of LH secretion by continuous kisspeptin infusion in healthy men. Hormones (Athens). 2026 Jun 2. doi: 10.1007/s42000-026-00795-y. Online ahead of print.
• Lippincott MF, Chan YM, Rivera Morales D, Seminara SB. Continuous Kisspeptin Administration in Postmenopausal Women: Impact of Estradiol on Luteinizing Hormone Secretion. J Clin Endocrinol Metab. 2017 Jun 1;102(6):2091-2099. doi: 10.1210/jc.2016-3952.

Drugs

Indications