drugset / Trial / NCT04180969
rTMS of Limbic Circuitry in Stress Modulation in Healthy Volunteers
RandomizedCrossoverTriple-blindBasic science
Summary
This study will be conducted with healthy male and female participants. Aim 1 will determine during sham repetitive transcranial magnetic stimulation (rTMS) how a drug stressor combination (yohimbine + hydrocortisone) relative to placebo alters : (1a) impulsivity; (1b) mood; and (1c) physiology. Aim 2 will determine whether active rTMS over the medial prefrontal cortex alters the effects of stress-exposure on (2a) decision-making, (2b) mood, and (2c) biomarkers of stress.
Timeline
- Start
- 2023-04-10
- Primary completion
- 2023-04-10
- Completion
- 2023-04-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Hydrocortisone | Other / unclassified | 20 mg | Oral |
| Subject | Yohimbine | Small molecule | 54 mg | Oral |
Indications
No indication recorded.