Safety and Efficacy of Prednisolone in Adrenal Insufficiency Disease (PRED-AID Study)

Summary

This study compares low-dose prednisolone therapy against standard regimens of hydrocortisone therapy for the treatment of adrenal insufficiency (AI). AI is a condition in which, individuals are unable to sufficiently produce the natural stress hormone, cortisol.

Timeline

Start

2019-07-31

Primary completion

2025-02-01

Completion

2025-02-01

Publications

• Choudhury S, Lazarus K, Sharma A, Narula K, Go C, Cro S, Thaventhiran T, Khoo B, Tan T, Meeran K. Prednisolone Once Daily vs Hydrocortisone Thrice Daily in Hypoadrenalism: A Randomized Clinical Trial. JAMA Netw Open. 2026 Mar 2;9(3):e262982. doi: 10.1001/jamanetworkopen.2026.2982.

Drugs

Indications