Safety and Efficacy of Prednisolone in Adrenal Insufficiency Disease (PRED-AID Study)

Phase 3 Unknown 44 enrolled Imperial College London Imperial Health Charity · collab National Institute for Health Research, United Kingdom · collab

RandomizedCrossoverQuadruple-blindTreatment

Summary

This study compares low-dose prednisolone therapy against standard regimens of hydrocortisone therapy for the treatment of adrenal insufficiency (AI). AI is a condition in which, individuals are unable to sufficiently produce the natural stress hormone, cortisol.

Timeline

Start: 2019-07-31
Primary completion: 2025-02-01
Completion: 2025-02-01

Outcome

Met primary endpoint

paper Bone turnover was significantly slowed with prednisolone compared with hydrocortisone PMID 41874506 ↗

Publications

Choudhury S, Lazarus K, Sharma A, Narula K, Go C, Cro S, Thaventhiran T, Khoo B, Tan T, Meeran K. Prednisolone Once Daily vs Hydrocortisone Thrice Daily in Hypoadrenalism: A Randomized Clinical Trial. JAMA Netw Open. 2026 Mar 2;9(3):e262982. doi: 10.1001/jamanetworkopen.2026.2982.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Hydrocortisone	Other / unclassified	—	—
Subject	Prednisolone	Other / unclassified	—	—