Initiation of Hydrocortisone for the Treatment of Septic Shock

Completed 118 enrolled Northern Jiangsu People's Hospital

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study : 1）to determine whether hydrocortisone is effective in the treatment of septic shock and 2) to identify the role of timing of low dose hydrocortisone administration in septic shock patients.

Timeline

Start: 2015-09
Primary completion: 2016-09
Completion: 2016-12

Outcome

Missed primary endpoint

paper There were no significant differences in 28-day or hospital all-cause mortality PMID 28615145 ↗

Publications

Lv QQ, Gu XH, Chen QH, Yu JQ, Zheng RQ. Early initiation of low-dose hydrocortisone treatment for septic shock in adults: A randomized clinical trial. Am J Emerg Med. 2017 Dec;35(12):1810-1814. doi: 10.1016/j.ajem.2017.06.004. Epub 2017 Jun 5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Hydrocortisone	Other / unclassified	200 mg	Other