Salivary Cortisol Measurement in Corticotrope Deficiency Substitution With Hydrocortisone.

Summary

Patients with adrenal insufficiency are most often overdosed with hydrocortisone. To date, there is no reliable marker that can reflect the quality of hydrocortisone substitution. Salivary cortisol is a good reflection of free plasmatic cortisol. However, salivary contamination with the oral intake of hydrocortisone has been described. The aims of the study are to: * evaluate the frequency of salivary contamination by hydrocortisone taken in tablet form and determine its risk factors. * evaluate the quality of hydrocortisone substitution in patients with corticotrope deficiency.

Timeline

Start

2021-01-01

Primary completion

2021-04-30

Completion

2021-04-30

Drugs

Indications