drugset

drugset / Trial / NCT03302416

CRF - Nociceptin Receptor Interactions

NCT03302416 ↗

Phase 0 Completed 19 enrolled University of Pittsburgh National Institute on Drug Abuse (NIDA) · collab

NaSingle-groupOpen-labelBasic science

Summary

To determine if \[C-11\]NOP-1A receptor binding (VT) can be altered by an intravenous hydrocortisone (cortisol) challenge through CRF-NOP interactions

Timeline

Start: 2016-06-01
Primary completion: 2019-06-01
Completion: 2019-06-01

Publications

Results Flanigan M, Tollefson S, Himes ML, Jordan R, Roach K, Stoughton C, Lopresti B, Mason NS, Ciccocioppo R, Narendran R. Acute Elevations in Cortisol Increase the In Vivo Binding of [11C]NOP-1A to Nociceptin Receptors: A Novel Imaging Paradigm to Study the Interaction Between Stress- and Antistress-Regulating Neuropeptides. Biol Psychiatry. 2020 Mar 15;87(6):570-576. doi: 10.1016/j.biopsych.2019.09.013. Epub 2019 Sep 25.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Hydrocortisone	Other / unclassified	1 mg/kg	Intravenous

Indications

No indication recorded.