CRF - Nociceptin Receptor Interactions

Phase 0 Completed 19 enrolled University of Pittsburgh National Institute on Drug Abuse (NIDA) · collab

NaSingle-groupOpen-labelBasic science

Summary

To determine if \[C-11\]NOP-1A receptor binding (VT) can be altered by an intravenous hydrocortisone (cortisol) challenge through CRF-NOP interactions

Timeline

Start: 2016-06-01
Primary completion: 2019-06-01
Completion: 2019-06-01

Outcome

Met primary endpoint

paper Regional [11C]NOP-1A VT was on average 11% to 16% higher in the post-hydrocortisone condition compared with the baseline condition PMID 31706582 ↗

paper linear mixed model, condition, p = .005 PMID 31706582 ↗

Publications

Results Flanigan M, Tollefson S, Himes ML, Jordan R, Roach K, Stoughton C, Lopresti B, Mason NS, Ciccocioppo R, Narendran R. Acute Elevations in Cortisol Increase the In Vivo Binding of [11C]NOP-1A to Nociceptin Receptors: A Novel Imaging Paradigm to Study the Interaction Between Stress- and Antistress-Regulating Neuropeptides. Biol Psychiatry. 2020 Mar 15;87(6):570-576. doi: 10.1016/j.biopsych.2019.09.013. Epub 2019 Sep 25.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Hydrocortisone	Other / unclassified	1 mg/kg	Intravenous

Indications

No indication recorded.