Imaging CRF X NOP Interactions in CUD

Summary

This study uses \[11C\]NOP-1A positron emission tomography (PET) and a hydrocortisone challenge to image the interaction between nociceptive opioid peptide (NOP) receptors and cortisol/corticotrophin releasing factor (CRF) in subjects with cocaine use disorders (CUD) and matched healthy controls (HC). It will also examine whether alterations in CRF x NOP interactions predict relapse in subjects with CUD.

Timeline

Start

2020-12-31

Primary completion

2028-09-01

Completion

2028-09-01

Drugs

Indications