Effect of Oral Sildenafil With Digital Therapeutic Iontophoresis of Sodium Nitroprussiate in Healthy Volunteers

Completed 40 enrolled University Hospital, Grenoble

Non-randomizedSingle-groupOpen-labelTreatment

Summary

Iontophoresis is a employed to facilitate drug absorption without systemic effect. This study investigates cutaneous microcirculation when we associate sildenafil per os with SNP via iontophoresis.

Timeline

Start: 2008-07
Primary completion: 2011-06
Completion: 2011-06

Publications

Background Cracowski JL, Minson CT, Salvat-Melis M, Halliwill JR. Methodological issues in the assessment of skin microvascular endothelial function in humans. Trends Pharmacol Sci. 2006 Sep;27(9):503-8. doi: 10.1016/j.tips.2006.07.008. Epub 2006 Jul 31.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Sildenafil	Unknown	—	Oral
Comparator	Sodium Nitroprussiate	Unknown	—	Other

Indications

No indication recorded.