drugset / Trial / NCT00716846
Effects of Statins on the Pharmacokinetics for Midazolam in Healthy Volunteers
RandomizedCrossoverOpen-labelTreatment
Summary
The purpose of this study is to investigate whether statins have any influence on cytochrome P450 (CYP) 3A4 enzyme activity using a probe drug midazolam.
Timeline
- Start
- 2006-06
- Primary completion
- 2008-07
- Completion
- 2008-08
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Atorvastatin | Small molecule | 10 mg | — |
| Comparator | Pitavastatin | Small molecule | 2 mg | — |
| Comparator | Simvastatin | Small molecule | 10 mg | — |
Indications
No indication recorded.