Therapeutic Effect of Two Fluoride Varnishes on White Spot Lesions: a Clinical Study

Phase 4 Completed 45 enrolled University of Pernambuco

RandomizedParallel-groupSingle-blindTreatment

Summary

The study hypothesis is the difference in therapeutic effect of two varnish formulations (G1 = NaF, 2.26%F, G2 = NaF, 2.71% F + CaF2). These products are commercially available in the Brazilian and international market and they are used for dental caries as white spot lesions control.

Timeline

Start: 2007-02
Primary completion: 2007-06
Completion: 2007-10

Outcome

Missed primary endpoint

paper WSL reductions were observed in both varnish groups (Chi-square = 0.15, d.f. = 1, P = 0.90) PMID 20027453 ↗

Publications

Ferreira JM, Aragao AK, Rosa AD, Sampaio FC, Menezes VA. Therapeutic effect of two fluoride varnishes on white spot lesions: a randomized clinical trial. Braz Oral Res. 2009 Oct-Dec;23(4):446-51. doi: 10.1590/s1806-83242009000400015.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	calcium fluoride	Unknown	6 %	—
Subject	sodium fluoride	Unknown	5 %	—