Phase 1b Study of Indibulin in Combination With Capecitabine in Advanced Solid Tumors

NCT00726687 ↗

Phase 1 Terminated 7 enrolled Alaunos Therapeutics

NaSingle-groupOpen-labelTreatment

Summary

This is a phase 1b study of Indibulin in combination with Capecitabine in advanced solid tumors.

Timeline

Start: 2008-06-19
Primary completion: 2009-09-29
Completion: 2009-09-29

Outcome

Outcome not reported

Stopped (Enrollment): “No dose-limiting toxicity was observed. The sponsor concluded the study after 3 subjects at the higher dose level; the optional 10-subject expansion cohort was not enrolled.”

Publications

Kapoor S, Srivastava S, Panda D. Indibulin dampens microtubule dynamics and produces synergistic antiproliferative effect with vinblastine in MCF-7 cells: Implications in cancer chemotherapy. Sci Rep. 2018 Aug 17;8(1):12363. doi: 10.1038/s41598-018-30376-y.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Capecitabine	Small molecule	—	—
Subject	indibulin	Small molecule	—	—