drugset / Trial / NCT00733720
Buprenorphine Naltrexone-P1 A-Cocaine
RandomizedCrossoverQuadruple-blindTreatment
Summary
The purpose of this study is to determine if the opioid agonist effects of doses of 4/1 mg, 8/2 mg, and 16/4 mg of buprenorphine/naloxone can be completely blocked by 50 mg of oral naltrexone. This study will provide data to support the design of a similar study of the depot formulation of naltrexone and ultimately to study this combination for the treatment of cocaine dependence.
Timeline
- Start
- 2008-08
- Primary completion
- 2008-12
- Completion
- 2009-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Buprenorphine | Other / unclassified | 4 mg | Other |
| Subject | Buprenorphine | Other / unclassified | 8 mg | Other |
| Subject | Buprenorphine | Other / unclassified | 16 mg | Other |
| Subject | Naloxone | Small molecule | 1 mg | Other |
| Subject | Naloxone | Small molecule | 2 mg | Other |
| Subject | Naloxone | Small molecule | 4 mg | Other |
| Subject | Naltrexone | Small molecule | 50 mg | Oral |