Comparison of the Analgesic Effects of Dronabinol and Smoked Marijuana in Daily Marijuana Smokers

Phase 2 Completed 34 enrolled New York State Psychiatric Institute National Institute on Drug Abuse (NIDA) · collab Research Foundation for Mental Hygiene, Inc. · collab

RandomizedCrossoverDouble-blindOther

Summary

The following study is designed to determine the analgesic efficacy of smoked marijuana (0, 1.98, and 3.56% THC) and oral THC (0, 10, and 20 mg) in the Cold-Pressor Test (CPT), a laboratory model of pain which has predictive validity for clinical use of analgesics. Oral THC (dronabinol) is known to have a slower onset and longer duration of action compared with smoked marijuana. Therefore, the analgesic effects of oral THC is expected to peak later and last longer than effects produced by smoked marijuana.

Timeline

Start: 2008-06
Primary completion: 2009-10
Completion: 2013-05

Publications

Background Cooper ZD, Comer SD, Haney M. Comparison of the analgesic effects of dronabinol and smoked marijuana in daily marijuana smokers. Neuropsychopharmacology. 2013 Sep;38(10):1984-92. doi: 10.1038/npp.2013.97. Epub 2013 Apr 22.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cannabis	Traditional medicine (herbal / TCM)	1.98 %	Inhaled
Subject	Cannabis	Traditional medicine (herbal / TCM)	3.56 %	Inhaled
Subject	Dronabinol	Other / unclassified	10 mg	Oral
Subject	Dronabinol	Other / unclassified	20 mg	Oral

Indications

No indication recorded.