drugset / Trial / NCT00743145
Effects of Low-dose Naltrexone in Combination With a Range of Smoked Marijuana
Phase 2
Completed
23 enrolled
New York State Psychiatric Institute
National Institute on Drug Abuse (NIDA) · collabResearch Foundation for Mental Hygiene, Inc. · collab
RandomizedCrossoverDouble-blindBasic science
Summary
In heavy marijuana smokers, opioid receptor blockade increases the subjective and cardiovascular effects of marijuana. The current study was designed to clarify opioid-cannabinoid interactions by assessing how naltrexone shifts the dose-response function for marijuana-elicited effects in heavy marijuana smokers. For this within-subject, double-blind study, a marijuana smoking procedure was designed to characterize a dose-response relationship for marijuana's subjective and cardiovascular effects under blinded conditions.
Timeline
- Start
- 2008-05
- Primary completion
- 2009-07
- Completion
- 2009-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cannabis | Traditional medicine (herbal / TCM) | 5.5 % | Inhaled |
| Subject | Cannabis | Traditional medicine (herbal / TCM) | 6.2 % | Inhaled |
| Subject | Naltrexone | Small molecule | 12 mg | — |
Indications
No indication recorded.