PREDnisolone-induced Beta-cell Dysfunction Prevented by EXenatide

Completed 8 enrolled Amsterdam UMC, location VUmc National Research Council, Institute of Biomedical Engineering · collab

RandomizedCrossoverDouble-blindTreatment

Summary

The purpose of this study is to explore whether the GLP-1 receptor agonist exenatide, may prevent glucocorticoid-induced glucometabolic abnormalities and beta-cell dysfunction in healthy subjects.

Timeline

Start: 2009-02
Primary completion: 2010-01
Completion: 2010-01

Publications

van Raalte DH, van Genugten RE, Linssen MM, Ouwens DM, Diamant M. Glucagon-like peptide-1 receptor agonist treatment prevents glucocorticoid-induced glucose intolerance and islet-cell dysfunction in humans. Diabetes Care. 2011 Feb;34(2):412-7. doi: 10.2337/dc10-1677. Epub 2011 Jan 7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Exenatide	Peptide	20 mg	Intravenous
Comparator	Prednisolone	Other / unclassified	80 mg	Oral

PREDnisolone-induced Beta-cell Dysfunction Prevented by EXenatide

Summary

Timeline

Publications

Drugs

Indications